Bilayer Lipid Membranes. Structure and Mechanical PropertiesIn Bilayer Lipid Membranes. Structure and Mechanical Properties the authors use new methods of measurement, which they have themselves developed, to present an analysis of the relation between membrane structure and viscoelastic properties, in particular in the transversal direction. Hianik and Passechnik's approach is fundamentally different from the usual one, in that they analyze lipid bilayer dynamics during various modes of deformation, arriving at a new, `three-layer' model that accounts for the great heterogeneity of biomembranes. The macroscopic parameters of membranes have been measured using a wide variety of methods, leading to a discussion of the correlations between the parameters. There is also an extensive discussion of the dynamic changes in mechanical properties of lipid bilayers in the course of conformational transition of integral proteins. During the conformational changes of proteins, the structure of a bilayer undergoes a transition, reaching a new, stable membrane state. The book is the first to present a comprehensive analysis of long-distance interaction in lipid bilayers and of molecular mechanisms of mechanoreception. Audience: Scientists and graduate students working in biophysics, membranology, physiology, medicine, pharmacology, bioelectronics, electrochemistry, and colloid chemistry. |
Contents
The elasticity and viscosity of biological membranes | 1 |
in a transversal direction | 19 |
55 | 76 |
Methods to measure the viscoelasticity of bilayer lipid membranes | 88 |
The peculiarity of the electrical field in membranes and an evaluation | 138 |
The bilayer lipid membrane as a viscoelastic body | 158 |
The application of the phenomena of the generation of higher current | 194 |
The mechanical properties of lipid bilayer under different action | 259 |
The mechanical and thermodynamical properties of lipid bilayer due to | 289 |
The distortion of the structure of lipid bilayer around membrane proteins | 348 |
The mechanics of lipid bilayers and the problems of mechanoreception | 371 |
Epilogue | 407 |
430 | |
Common terms and phrases
A₁ AC/C amplitude applied approximately bacteriorhodopsin Berestovsky bilayer lipid membranes bilayer membranes biological membranes biomembranes Biophys brane Ca-ATPase calculated capacitance cell characteristics cholesterol cholesterol concentration coefficient compressibility constant corresponding current harmonic curve decrease deformation determined E₁ effect elasticity modulus electric field electrolyte electrostriction experimental force formation frequency dependence gramicidin Hianik hydrophobic increase influence inhomogeneous insulin interaction ion channel ionic kinetics layer lecithin lipid bilayer lipid composition lipid solution liposomes macromolecule measured mechanical properties mechanosensitivity membrane capacitance membrane plane method mg/ml microinhomogeneities modulus of elasticity mol/l molecules n-heptane nonlinearity obtained oscillations oxidized cholesterol parameters Passechnik V. I. phospholipid planar proteins receptor regions relationship relative changes roughness Russian s-BLM SBPC shown solvent structure surface potential symmetric temperature tension thickness torus transversal viscoelastic voltage volume compressibility Wobschall Young modulus