Research Methods in Occupational EpidemiologyOccupational epidemiology has emerged as a distinct subdiscipline of epidemiology and occupational medicine, addressing fundamental public health and scientific questions relating to the specification of exposure-response relationships, assessment of the adequacy of occupational exposure guidelines, and extrapolation of hazardous effects to other settings. This book reviews the wide range of principles and methods used in epidemiologic studies of working populations. It describes the historical development of occupational epidemiology, the approaches to characterizing workplace exposures, and the methods for designing and implementing epidemiologic studies. The relative strengths and limitations of different study designs are emphasized. Also included are more advanced discussions of statistical analysis, the estimation of doses to biological targets, and applications of the data derived from occupational epidemiology studies to disease modeling and risk assessment. The volume will serve both as a textbook in epidemiology and occupational medicine courses and as a practical handbook for the design, implementation, and interpretation of research in this field. |
Contents
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References | 14 |
Glossary | 43 |
Glossary | 68 |
Glossary | 98 |
Glossary | 165 |
Glossary | 198 |
Glossary | 229 |
Glossary | 260 |
Glossary | 287 |
The ArmitageDoll Multistage Model of Carcinogenesis | 293 |
Glossary | 329 |
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Common terms and phrases
analysis approach asbestos asbestos exposure asbestos textile assumed biological carcinogen case-control study Chapter comparison group computed confidence interval confounding considered controls cross-sectional studies cumulative exposure death disease rates dose-response effect estimates employment duration Environ Health Epidemiol epidemiologic epidemiologic studies example expected numbers expo exposure category exposure data exposure intensity exposure levels function Healthy Worker Effect historical cohort study industry involves job categories latency length of follow-up logistic regression lung cancer lung cancer mortality Mantel-Haenszel matched measure methods Miettinen mortality study non-exposed observed obtained occupational cohort occupational epidemiology occupational exposures occur odds ratio organ burden period person-time person-years persons plant Poisson regression potential prevalence proportional proportional hazards model rate ratio reference population relative risk respiratory risk assessment risk factors Rothman sampling selection sources statistical strata stratified stratum stratum-specific study base study design subcohort substance Table target tion uranium variables vital status workers exposed