Adult Neurogenesis and Neural Stem Cells in MammalsThis title contains a book and CD. The brain has a number of nerve cells estimated at a magnitude of 10 to 100 billion, and 1014 to 1015 synapses, and therefore is the most complex organ of the human body. During fetal development the foundations of the brain are laid as billions of neurons form appropriate connections and patterns. In the adult mammalian brain, most neurons are post-mitotic, and therefore at risk for irreversible damage. As we age, atrophy of the brain occurs. As brain weight declines the volume of the brain in the 8th decade is reduced by 6 per cent -10 per cent versus the third decade, and neuronal loss occurs, up to 10,000 to 100,000 neurons are lost per day, though this estimation is being revised downward with the advance of more sophisticated measurements. |
Contents
11 | |
21 | |
35 | |
Modulation of Neurogenesis in the Adult Brain | 53 |
Broader Potential of Adult Stem Cells | 65 |
Neurogenesis in Neurodegenerative and Neurological Diseases | 77 |
Neurogenesis in Ischemic Strokes | 97 |
Neurogenesis in Traumatic Brain Injury | 109 |
Adult Retinal Stem Cells | 125 |
Adult Neurogenesis and Regeneration Repairing and Healing the CNS | 131 |
Adult Neurogenesis and Neuroplasticity | 145 |
Adult Neurogenesis and Neuroadaptation | 151 |
Cancer Stem Cells and Brain Tumor Stem Cells | 165 |
Cellular Therapy in the Central Nervous System | 175 |
Conclusion and Perspectives | 195 |
Index | 197 |
Common terms and phrases
Acad Sci USA adult brain adult CNS adult mammalian brain adult mice adult neurogenesis adult rat adult spinal cord adult stem cells Alvarez-Buylla astrocytes bone marrow Brain Res brain tumors BrdU cell cycle cell death cell proliferation cellular therapy central nervous system Comp Neurol cystatin dentate gyrus differentiate into neuronal embryonic endogenous epilepsy expression forebrain Gage FH gene glial cells granule cell hematopoietic hippocampal neurogenesis induced ischemic Kempermann Kuhn HG layer marker mechanisms migration molecular molecules multipotent Natl Acad Sci nestin neural progenitor cells neural stem cells Neurobiol neurogenesis occurs neurogenic neurological diseases neuronal cells neuronal precursors Neurosci Neurosci Res neurospheres newly generated cells newly generated neuronal olfactory bulb oligodendrocytes phenotypes population potential of adult Proc Natl Acad progenitor and stem protein receptor regulation retina seizures self-renewing multipotent spinal cord stimulates neurogenesis studies subventricular zone tissues traumatic brain injury vitro vivo Zhang
Popular passages
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References to this book
Phytochemicals: Aging and Health Mark S. Meskin,Wayne R. Bidlack,R. Keith Randolph Limited preview - 2008 |