Synthetic Surfactant Vesicles: Niosomes and Other Non-Phospholipid Vesicular SystemsThe self-assembly of synthetic surfactants and other non-phospholipids into vesicles was first studied in the 1970s by cosmetic scientists when non-ionic surfactant vesicles or niosomes were reported. Since this time a large body of research has sought to define these systems primarily as drug carriers and also as features of interest to the colloid scientist. Synthetic surfactant vesicles, as the name implies, may also be fabricated from a vast array of amphiphiles, including a number of pharmaceutically acceptable materials. They may also be prepared in a variety of shapes and sizes and have a number of applications. This book is designed to serve as an introductory text to the science of non-phospholipid vesicles and will be of use to colloid, drug delivery, cosmetic, and materials scientists. It aims to acquaint the reader with the physicochemistry and biomedical applications of these synthetic surfactant non-phospholipid vesicles. Part one introduces the reader to physicochemical aspects of these synthetic surfactant dispersions and explores the diversity of materials that may be used to formulate vesicles. Part two details methods of vesicle preparation and the application of synthetic surfactant vesicles in a variety of fields ranging from anti-cancer chemotherapy to immunization. |
Contents
BIRTH OR REBIRTH? | 3 |
2 MOLECULAR MODELLING OF SURFACTANT VESICLES | 10 |
3 RHEOLOGY OF NIOSOME DISPERSIONS | 28 |
4 NONIONIC SURFACTANT VESICLE TO MICELLE TRANSITIONS | 55 |
NIOSOME PREPARATION AND APPLICATIONS | 91 |
5 PRONIOSOMES | 93 |
6 NONIONIC SURFACTANT VESICLES FOR THE TREATMENT OF VISCERAL LEISHMANIASIS | 108 |
7 NIOSOMES AND OTHER SYNTHETIC SURFACTANT VESICLES WITH ANTITUMOUR DRUGS | 129 |
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Synthetic Surfactant Vesicles: Niosomes and Other Non-Phospholipid Vesicular ... L F Uchegbu No preview available - 2000 |
Common terms and phrases
addition adjuvant activity administration aggregates amphiphiles antibody antigen application aqueous associated bilayer carriers cells Cevc changes characteristics cholesterol compared concentration demonstrated described detergent determined diameter dilution dispersions dose drug delivery effect efficiency emulsion encapsulated enhanced entrapped et al experiments Figure Florence formation formulations function groups higher human hydration ibuprofen immune improved increase indicated induced injection interaction layers levels limited lipid liposomes mean membrane method mice micelles mixed molecular molecules niosomes NISV non-ionic surfactant observed obtained organic particles Pharm phase phospholipid prepared present produced production properties ratio release responses Rogerson shape showed shown skin solubilization solution Span 60 specific stability stratum corneum structures studies surfactant vesicles suspension Table temperature tissue toxicity transition tumour Uchegbu v/w/o gel vaccines vesicular viscosity vitro vivo volume