Principles of Molecular Virology (Standard Edition)Principles of Molecular Virology, Fourth Edition provides an essential introduction to modern virology in a clear and concise manner. It is a highly enjoyable and readable text with numerous illustrations that enhance the reader's understanding of important principles.
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Page 18
... subunits in a virus capsid to reveal the fine structure of the particle. Using such data, Francis Crick and James Watson (1956) were the first to suggest that virus capsids are composed of numerous identical protein subunits arranged ...
... subunits in a virus capsid to reveal the fine structure of the particle. Using such data, Francis Crick and James Watson (1956) were the first to suggest that virus capsids are composed of numerous identical protein subunits arranged ...
Page 27
... subunits may render that particular subunit nonfunctional, but rarely does limited damage destroy the infectivity of the entire particle.This makes the capsid an effective barrier. The protein shells surrounding virus particles are very ...
... subunits may render that particular subunit nonfunctional, but rarely does limited damage destroy the infectivity of the entire particle.This makes the capsid an effective barrier. The protein shells surrounding virus particles are very ...
Page 28
... (subunit construction), and viruses must overcome the problem of how these subunits are arranged. In 1957, Fraenkel-Conrat and Williams showed that, when mixtures of purified tobacco mosaic virus (TMV) RNA and coat protein were incubated ...
... (subunit construction), and viruses must overcome the problem of how these subunits are arranged. In 1957, Fraenkel-Conrat and Williams showed that, when mixtures of purified tobacco mosaic virus (TMV) RNA and coat protein were incubated ...
Page 29
... subunits, helices are described by the number of subunits per turn of the helix, m, and the axial rise per subunit, p; therefore, the pitch of the helix, P, is equal to: P =μ× p For TMV, μ = 16.3; that is, there are 16.3 coat protein ...
... subunits, helices are described by the number of subunits per turn of the helix, m, and the axial rise per subunit, p; therefore, the pitch of the helix, P, is equal to: P =μ× p For TMV, μ = 16.3; that is, there are 16.3 coat protein ...
Page 30
... subunit to form a particle is confirmed by the large number of different types of virus that have evolved with this ... subunits overlapping like the scales of a fish. Other capsid proteins required for the biological activity of the ...
... subunit to form a particle is confirmed by the large number of different types of virus that have evolved with this ... subunits overlapping like the scales of a fish. Other capsid proteins required for the biological activity of the ...
Contents
1 | |
25 | |
Chapter 3 Genomes | 56 |
Chapter 4 Replication | 102 |
Chapter 5 Expression | 131 |
Chapter 6 Infection | 165 |
Chapter 7 Pathogenesis | 208 |
Genomes Without Viruses Viruses Without Genomes | 249 |
Appendix 1 Glossary And Abbreviations | 269 |
Appendix 2 Classification of Subcellular Infectious Agents | 281 |
Appendix 3 The History Of Virology | 294 |
Index | 300 |
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Common terms and phrases
activation addition agents allow altered animals antibodies antigen appear assembly associated Bacteria bacteriophages binding biology capsid cause cellular changes Chapter complex consist contain cytoplasm dependent described determined direct disease drugs early effects encode envelope enzymes example expression factors families Figure formation function further gene gene expression genetic groups host cell human immune system important infected cells influenza initiation interaction involved known major mature mechanisms membrane molecular molecules mRNAs mutations nature normal nucleic acid nucleotide nucleus occurs organisms packaged particular phage Plants polymerase possible present produced promoter proteins receptor region regulation relatively release replication response result retroviruses reverse segments sense sequence similar single specific stages strand structure subunits surface techniques tion transcription transformation translation transmission tumour usually vaccines vectors Vertebrates virion virology virus genome virus infection virus particles virus replication viruses
Popular passages
Page 129 - Schneider-Schaulies, J. 2000. Cellular receptors for viruses: links to tropism and pathogenesis.
Page 129 - JA (2004) The CCR5 and CXCR4 coreceptors central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses 20: 1 1 1-26.
Page x - Press for their support and assistance during the preparation of the book. Finally, I would like to thank my family for respecting the sign which has spent many hours on the door of my study, 'I am working. Please don't come in'.
Page 128 - Kasamatsu. H.. and Nakanishi. A. (1998). How do animal DNA viruses get to the nucleus? Annu. Rev. Microbiol.
Page 23 - Rohwer, F., and Edwards, R. (2002). The Phage Proteomic Tree: a genome-based taxonomy for phage. J.
Page 163 - J, et al (2002) Molecular Biology of the Cell, 4th Ed. Garland Science, New York Berger SI, (2002) Historic modifications in transcriptional regulation.
Page 3 - The disease must be reproduced when a pure culture of the agent is inoculated into a healthy susceptible host. • The same agent must be recovered once again from the experimentally infected host. Subsequently, Pasteur worked extensively on rabies, which he identified as being caused by a 'virus...
Page 281 - a virus species is a polythetic class of viruses that constitute a replicating lineage and occupy a particular ecological niche
Page 100 - Young. 2004. The structure of a thermophilic archaeal virus shows a double-stranded DNA viral capsid type that spans all domains of life. Proc.
Page 267 - Taylor, JM 2003. Replication of human hepatitis delta virus: recent developments.