Bacterial Genomes and Infectious DiseasesRicky V.L Chan, Philip M. Sherman, Billy Bourke The first bacterial genome, Haemophilus influenzae, was completely sequenced, annotated, and published in 1995. Today, more than 200 prokaryotic (archaeal and bacterial) genomes have been completed and over 500 prokaryotic genomes are in va- ous stages of completion. Seventeen eukaryotic genomes plus four eukaryotic chro- somes have been completed. The concept of achieving better understanding of an organism through knowledge of the complete genomic sequence was first demonstrated in 1978 when the first bacteriophage genome, X174, was sequenced. Complete genomic sequences of prokaryotes have led to a better understanding of the biology and evolution of the microbes, and, for pathogens, facilitated identification of new vaccine candidates, putative virulence genes, targets for antibiotics, new strategy for rapid diagnosis, and investigation of bacteria–host interactions and disease mec- nisms. Recent increased interest in microbial pathogens and infectious diseases is largely attributed to the re-emergence of infectious diseases like tuberculosis, emergence of new infectious diseases like AIDS and severe acute respiratory syndrome, the problem of an increasing rate of emergence of antibiotic-resistant variants of pathogens, and the fear of bioterrorism. Microbes are highly diverse and abundant in the biosphere. Less than 1% of these morphologically identified microbes can be cultured in vitro using standard techniques and conditions. With such abundance of microbes in nature, we can expect to see new variants and new species evolve and a small number will emerge as pathogens to humans. |
Contents
Evolution and Origin of Virulence Isolates | 21 |
Genomic Approach to Understanding Infectious | 31 |
Knockout and Disease Models in TollLike | 41 |
From Glycome to Pathogenesis | 63 |
Genomics of Helicobacter Species | 91 |
The Organization of Leptospira at a Genomic Level | 109 |
Listeria monocytogenes | 125 |
Mycobacterial Genomes | 151 |
Other editions - View all
Bacterial Genomes and Infectious Diseases Ricky V.L Chan,Philip M. Sherman,Billy Bourke No preview available - 2016 |
Bacterial Genomes and Infectious Diseases Ricky V.L Chan,Philip M. Sherman,Billy Bourke No preview available - 2006 |
Bacterial Genomes and Infectious Diseases Ricky V.L Chan,Philip M. Sherman,Billy Bourke No preview available - 2008 |
Common terms and phrases
Acad acid activation addition analysis antigenic associated bacterial Bacteriol bacteriophage Biol Campylobacter carry cause cell characterization cholerae chromosome Clin cluster coli common Comparative complete conserved contains deletion described determined disease diversity domain effects elements encoding et al evolution example expression function genes genes encoding genetic genome sequence glycan glycosylation Helicobacter host human identified Immun important indicates infection intestinal involved islands isolates jejuni known lipoproteins Listeria monocytogenes major mechanisms mice microarray Microbiol molecular multiple mutations Mycobacterium Mycoplasma Nature novel ORFs organisms pathogenesis pathogens pathway pestis plasmid pneumoniae present PrfA Proc production promote proteins pseudotuberculosis pylori recent region regulation resistance response role Science secretion showed signaling similar species Staphylococcus aureus strains structure studies suggesting surface Table tion toxin transcription tuberculosis variation Vibrio Vibrio cholerae virulence vulnificus Yersinia