Regulation of Diethylstilbestrol (DES): (its Use as a Drug for Humans and in Animal Feeds). Hearing Before a Subcommittee of the Committee on Government Operations, House of Representatives, Ninety-second Congress, First Session, Part 2U.S. Government Printing Office, 1972 - Diethylstilbestrol |
Common terms and phrases
aflatoxin Amprolium analysis analytical animal drug antibiotic AOAC 11 as/FAR assay Bacitracin billion bioassay biological BROWN of Ohio Bureau carcinogenic cattle Chairman chemical carcinogens Chlortetracycline Committee CONGRESS THE LIBRARY containing curve December Delaney clause detection diet diethylstilbestrol discussed dose dose-response Drug Administration EDWARDS effect environment environmental estimated estrogenic experimental extrapolation food additive Food and Drug food supply Friedman gm/ton GOLDHAMMER hazard hearing HOUWELING HUTT Hygromycin incidence inspection L. H. FOUNTAIN label laboratory Lehmann Leo Friedman LIBRARY OF CONGRESS liver Mantel and Bryan Mantel-Bryan medicated feed memorandum ment method mice mouse MUSSMAN National Cancer Institute paragraph Penicillin percent positive problem procedure question regulations regulatory residues response risk safe level safety evaluation safety factor samples sensitivity SIMMONS slaughter specific staff stilbestrol Subcommittee substance Sulfanitran test animals tion tissue toxicity Toxicology tumors Tylosin USDA virtually safe withdrawal period Wodicka zero
Popular passages
Page 219 - ... publication in the FEDERAL REGISTER file with the Hearing Clerk, Department of Health, Education, and Welfare, Room 5440, 330 Independence Avenue SW., Washington 25, DC, written objections thereto.
Page 213 - ... (B) the cumulative effect of such additive in the diet of man or animals, taking into account any chemically or pharmacologically related substance or substances in such diet; and (C) safety factors which in the opinion of experts qualified by scientific training and experience to evaluate the safety of food additives are generally recognized as appropriate for the use of animal experimentation data.
Page 219 - Objections shall show wherein the person filing will be adversely affected by the order and specify with particularity the provisions of the order deemed objectionable and the grounds for the objections. If a hearing is requested, the objections must state the issues for the hearing, and such objections must be supported by grounds legally sufficient to justify the relief sought.
Page 147 - Institute of Environmental. Medicine, New York University Medical Center, New York, New York Dr.
Page 226 - ... will be found (by methods of examination prescribed or approved by the Secretary by regulations, which regulations shall not be subject to...
Page 213 - Except where evidence is submitted which justifies use of a different safety factor, a safety factor in applying animal experimentation data to man of 100 to 1, will be used; that is, a food additive for use by man will not be granted a tolerance that will exceed l/100th of the maximum amount demonstrated to be without harm to experimental animals.
Page 213 - In determining, for the purposes of this section, whether a proposed use of a food additive is safe, the Secretary shall consider among other relevant factors...
Page 235 - Again, we say, however, that we believe the issue is so Important that the elected Representatives of the people should have the opportunity of examining the evidence and determining whether or not the authority should be granted.
Page 169 - No one at this time can tell how much or how little of a carcinogen would be required to produce cancer in any human being, or how long it would take the cancer to develop.
Page 224 - The existence of natural estrogen in foodstuffs does not warrant the intake of DES by a deliberate means of exposure through the implantation of such drug in a chicken so as to make it tastier and to save feed costs. If estrogens are contained naturally in certain items of diet, there is no justification for adding more by an artificial method.