Free Radical Mechanisms of Tissue InjuryThis timely volume describes the contributions of free radicals and reactive oxygen species to disease processes in a variety of tissues. Topics include the roles of lipid peroxide-modified lipoproteins in atherosclerosis, peroxidation products in retinopathy, reactive oxygen species and neutrophils in mycardial ischemia-reflow injury, iron and reactive oxygen species in hemoglobin-mediated CNS damage and in asbestos-mediated lung injury. Critical reviews examine the evidence for radical species in ethanol-induced liver injury and in muscular dystrophy. The wealth of new information presented makes this book valuable for teaching and an important reference volume for researchers exploring problems in human disease. |
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Acad activity alcohol antioxidant arachidonic acid artery arylamines asbestos ascorbate atherosclerosis binding Biochem Biol biological Biophys Ca2+ calcium canine cardiac catalase cell injury cellular Chem chemical chemotactic Clin concentrations coronary cytosolic cytotoxicity damage disease effects endothelial cells endothelium ethanol evidence factor formation free radicals function GSSG H₂O₂ heart hemoglobin human neutrophils hydrogen peroxide hydroperoxide increased incubated induced infarct inhibition inhibitors interactions intracellular iron ischemic isolated leukocytes leukotriene lipid peroxidation lipoxygenase liver low density lipoprotein lung macrophages mechanisms mediated metabolism metabolites microsomal mitochondrial molecular molecules muscle muscular dystrophy myocardium myocytes NADPH necrosis neutrophil neutrophil adhesion O₂ oxidant stress perfused Pharmacol Physiol plasma membrane postischemic potential production prostaglandin protein rabbit reactions reactive oxygen species receptor reduced respiratory burst response retinal role scavenger stimulated studies substrate superoxide dismutase t-bu-OOH tissue injury toxicity vascular vitamin vitamin E vitro vivo xanthine oxidase