Sensory Neurons: Diversity, Development, and Plasticity

Front Cover
Vertebrate sensory neurons occupy a unique place in the nervous system, conveying information from the periphery to the CNS. While sensory physiologists have long recognized differences in response properties among cells in dorsal root and cranial ganglia, the full extent of heterogeneity among these neurons has only recently become apparent. Phenotypic diversity is the underlying theme of this unique work, which summarizes our current understanding of the individual characteristics and development of sensory neurons. The chapters are arranged in three cohesive sections. The first describes heterogeneity in the function, biochemical make-up, ion channels, membrane properties, and central projection patterns of dorsal root ganglion neurons. The second section discusses the development of sensory neurons, covering such topics as the origins of dorsal root and cranial ganglia, adhesive interactions involved in axon outgrowth, trophic dependence of sensory neurons, and the development of the physiological properties and central and peripheral connections of dorsal root ganglion neurons. The last section explains regeneration and plasticity of mature neurons, including sprouting of skin sensory axons, plasticity in central terminations, axotomy and regeneration, and the continuing role of neurotrophic factors in adult neurons.

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Contents

An Overview
3
Morphological and Biochemical Cell Types of Sensory Neurons
27
The Organization of Biochemically Characterized Sensory
60
Functional Heterogeneity of Dorsal Root Ganglion Cells
77
VoltageGated lon Channels in Dorsal Root Ganglion Neurons
97
Somatotopic Organization of Primary Afferent Projections to
116
Laminar Organization of Primary Afferent Terminations in
131
The Cellular and Molecular Basis of Early Sensory Ganglion
143
The Development of Peripheral Sensory Innervation Patterns
242
The Development of Muscle Afferent Connections in the Vertebrate
264
The Physiological Properties of Developing Sensory Neurons
287
Trophic Control
309
Plasticity of Central Terminations of Primary Sensory Neurons in
333
AxotomyInduced Changes in Primary Sensory Neurons
363
Specificity of Regenerating Sensory Neurons in Adult Mammals
384
The Role of Neurotrophic Factors in Functional Maintenance
404

Neurons
171
Cell Death and the Trophic Requirements of Developing Sensory
194
Adhesive Interactions That Regulate Neuronal Behavior
215

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About the author (1992)

Sheryl A. Scott is at State University of New York, Stony Brook.

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