Sensory Neurons: Diversity, Development, and PlasticitySheryl A. Scott Vertebrate sensory neurons occupy a unique place in the nervous system, conveying information from the periphery to the CNS. While sensory physiologists have long recognized differences in response properties among cells in dorsal root and cranial ganglia, the full extent of heterogeneity among these neurons has only recently become apparent. Phenotypic diversity is the underlying theme of this unique work, which summarizes our current understanding of the individual characteristics and development of sensory neurons. The chapters are arranged in three cohesive sections. The first describes heterogeneity in the function, biochemical make-up, ion channels, membrane properties, and central projection patterns of dorsal root ganglion neurons. The second section discusses the development of sensory neurons, covering such topics as the origins of dorsal root and cranial ganglia, adhesive interactions involved in axon outgrowth, trophic dependence of sensory neurons, and the development of the physiological properties and central and peripheral connections of dorsal root ganglion neurons. The last section explains regeneration and plasticity of mature neurons, including sprouting of skin sensory axons, plasticity in central terminations, axotomy and regeneration, and the continuing role of neurotrophic factors in adult neurons. |
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Contents
An Overview | 3 |
Morphological and Biochemical Cell Types of Sensory Neurons | 27 |
The Organization of Biochemically Characterized Sensory | 60 |
Functional Heterogeneity of Dorsal Root Ganglion Cells | 77 |
VoltageGated Ion Channels in Dorsal Root Ganglion Neurons | 97 |
Somatotopic Organization of Primary Afferent Projections to | 116 |
Laminar Organization of Primary Afferent Terminations in | 131 |
The Cellular and Molecular Basis of Early Sensory Ganglion | 143 |
The Development of Peripheral Sensory Innervation Patterns | 242 |
The Development of Muscle Afferent Connections in the Vertebrate | 264 |
The Physiological Properties of Developing Sensory Neurons | 287 |
Trophic Control | 309 |
Plasticity of Central Terminations of Primary Sensory Neurons in | 333 |
AxotomyInduced Changes in Primary Sensory Neurons | 363 |
Specificity of Regenerating Sensory Neurons in Adult Mammals | 384 |
The Role of Neurotrophic Factors in Functional Maintenance | 404 |
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Common terms and phrases
activity adhesion molecules adult rat afferent fibers afferent units antibodies axotomy BDNF Biol Brain Res C-fiber Ca2+ central terminals CGRP chick embryo collateral sprouting Comp conduction velocity cranial sensory cutaneous afferents Davies denervated dermatomes dorsal horn dorsal horn cells dorsal root ganglion Douarin DRG cells DRG neurons expression FRAP function ganglion cells hindlimb immunoreactivity innervation integrin interactions Koerber labeled lamina Lawson Lindsay Lond mechanoreceptors Merkel cells monosynaptic motoneurons mRNA muscle afferents muscle spindles myelinated nerve growth factor nervous system neural crest cells neurite Neurophysiol Neurosci neurotrophic factor NGF receptor nociceptive nociceptors normal pattern peptide peripheral nerve Physiol placodes primary afferent primary sensory neurons projections protein rat dorsal root rat DRG receptive fields regeneration reinnervation response rons root ganglion cells sensory ganglia skin somatotopic somite SP-LI specific spikes spinal cord stimulation studies substance survival synaptic target field Thoenen tissue trigeminal unmyelinated vitro