Microsystem Technology: A Powerful Tool for Biomolecular Studies

Front Cover
Hans-Peter Saluz, M. Köhler, T. Mejevaia
Springer Science & Business Media, Jun 1, 1999 - Science - 581 pages
Biomolecular studies are the trial of Man to understand how Nature manages information at the molecular level. The understanding of molecular informa tion handling in nature is essential for the molecular optimization in chem istry, molecular biology, molecular pharmacology and therefore - as an ex ample - for the development of specifically acting drugs. The famous recent method of technical information management is digital electronics. Over the past few years, evidence has arisen that computerized and molecular information managements have many similar and overlapping aspects. For example, both technology and nature use digitized information and both use small structures for the efficient handling of information. Furthermore, they optimize their processes in order to gain a maximum of information with a minimum of invested energy. During the last two decades, novel experimental techniques in biomolec ular sciences have paved the way for artificial biomolecular optimization. In the same time interval, the progress of micro system technology has been extended from the field of digital electronics and sensing to micro liquid hand ling, and the field of chip-supported substance handling began. It appears that the "marriage" of physical micro technology and molecular processing will be consummated soon. The contact of both fields has been realized in for ex ample DNA chips. Such connections will also become relevant in additional fields in the near future. Biomolecular investigations are the first to profit from these fast growing scientific and technical connections between micro systems and molecular sciences.
 

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Contents

Molecular building principles in nature
1
Robotic equipment and microsystem technology in biological research
17
Components and systems for microliquid handling
31
Nanotiterplates for screening and synthesis
75
Chip technology for microseparation
129
Rapid multisample PCR in miniaturized ultrathinwalled microwell plates
179
Generation of large libraries
189
Generation and screening of solutionphase synthetic peptide combinatorial libraries
206
Fluorescence correlation spectrometry FCS Measuring biological interactions in microstructures
311
Scanning force microscopy A microstructured device for imaging probing and manipulation of biomolecules at the nanometer scale
333
DNA resequencing mutation detection and gene expression analysis by oligo nucleotide microchips
351
Miniaturized arrays for DNA analysis
379
Manipulation of particles cells and liquid droplets by high frequency electric fields
397
Optical trapping and manipulation
433
Computer modeling of protein nucleic acid and drug structures
455
Optimizing structure and function relationship of nucleic acid molecules
487

Using oligonucleotide probe arrays to access genetic diversity
221
Generation of libraries by print technologies
235
Synthesis and screening of beadbased libraries
245
Sensors for biomolecular studies
259
Fluorescence detection of single molecules applicable to small volume assays
291
Optimisation of molecular function
509
Udo Luhmann
535
Index
555
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