Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity DrugsTim Kirkham, Steven J Cooper There is now enough basic work to sketch out the principal systems at all levels of the brain, from prefrontal cortex to lower brainstem, which are orchestrated to provide control of food selection, preference and consumption. At the same time, the complex interplay between central systems and signals generated from peripheral systems include the gut, liver and fat stores, as well as the interactions with the neuroendocrine system can be described in some detail. A continuing theme throughout the book is that the functional analysis of appetite and food intake cannot be limited to a single focus, e.g. hypothalamic neuropeptides and their interactions, but must be based on a fully integrated view of the several contributing systems. Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs provides an expert guide to the neural, neurochemical, autonomic and endocrine interrelations which underpin appetite and the controls of food intake and body weight. The book covers many of the neurochemical entities that are currently under investigation, including: neuropeptides, leptin, insulin, monoamines and endogenous cannabinoids in relation to appetite and body-weight control. In addition to the neuroscience analysis, there are also chapters that provide an expert guide to some of the key psychological concepts that the researchers believe are essential in trying to understand the phenomena under investigation. The volume will also serve as an authoritative guide to the current emphasis on the development of novel, efficacious anti-obesity medication.
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From inside the book
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... endogenous GABA at terminals (Halonen et al., 1991). The fact that feeding is induced by inhibiting AcbSh GABA metabolism indicates that there is a tonic release of GABA in the region and that GABA tone in the AcbSh is maintained, in ...
... endogenous neuroactive compounds can alter food intake when administered in the AcbSh, reinforcing the idea that AcbSh neural circuits integrate varied information from numerous sources that serve as parameters in the neural ...
... endogenous ligand for the ORL1 receptor, dose-dependently increases food intake without altering locomotor activity (Stratford et al., 1997). As with manipulations of the amino acid systems, there is a very short latency to begin ...
... endogenous cannabinoids anandamide and 2-AG by 200 to 300% in the limbic forebrain, an area encompassing the AcbSh (Kirkham et al., 2002). Levels were not changed in rats consuming a palatable diet, suggesting that endocannabinoid ...
... endogenous glutamate levels in the AcbSh are tightly correlated with feeding behavior and that a reduction in AcbSh activity is involved in initiating feeding behavior. • Food deprivation alters peptide levels in the AcbSh. Acute food ...
Contents
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67 | |
BrainstemHypothalamic Neuropeptides and the Regulation of Feeding | 99 |
The GutBrain Axis in the Control of Eating | 143 |
Integration of Peripheral Adiposity Signals and Psychological Controls of Appetite | 167 |
Brain Reward Systems for Food Incentives and Hedonics in Normal Appetite and Eating Disorders | 191 |
The Role of Palatability in Control of Human Appetite Implications for Understanding and Treating Obesity | 247 |
Learned Influences on Appetite Food Choice and Intake Evidence in Human Beings | 271 |
Gene Environment Interactions and the Origin of the Modern Obesity Epidemic A Novel Nonadaptive Drift Scenario | 301 |
Preclinical Developments in Antiobesity Drugs | 323 |
Clinical Investigations of Antiobesity Drugs | 337 |
Index | 357 |
Color Plates | 373 |
Pharmacology of Food Taste and Learned Flavor Preferences | 217 |
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Appetite and Body Weight: Integrative Systems and the Development of Anti ... Tim C. Kirkham,S. J. Cooper No preview available - 2007 |