Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity DrugsTim Kirkham, Steven J Cooper There is now enough basic work to sketch out the principal systems at all levels of the brain, from prefrontal cortex to lower brainstem, which are orchestrated to provide control of food selection, preference and consumption. At the same time, the complex interplay between central systems and signals generated from peripheral systems include the gut, liver and fat stores, as well as the interactions with the neuroendocrine system can be described in some detail. A continuing theme throughout the book is that the functional analysis of appetite and food intake cannot be limited to a single focus, e.g. hypothalamic neuropeptides and their interactions, but must be based on a fully integrated view of the several contributing systems. Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs provides an expert guide to the neural, neurochemical, autonomic and endocrine interrelations which underpin appetite and the controls of food intake and body weight. The book covers many of the neurochemical entities that are currently under investigation, including: neuropeptides, leptin, insulin, monoamines and endogenous cannabinoids in relation to appetite and body-weight control. In addition to the neuroscience analysis, there are also chapters that provide an expert guide to some of the key psychological concepts that the researchers believe are essential in trying to understand the phenomena under investigation. The volume will also serve as an authoritative guide to the current emphasis on the development of novel, efficacious anti-obesity medication.
|
From inside the book
Results 1-5 of 63
... paraventricular hypothalamic nuclei. The AcbSh appears to mediate activity in the lateral hypothalamus both through direct projections and by altering the firing rate of neurons in the interposed medial ventral pallidum. The magnitude ...
... nuclei are specific, unitary entities, it should be remembered that each contains ... NUCLEUS ACCUMBENS SHELL It has been recognized since the 1970s that ... paraventricular hypothalamic regions. A. Excitatory and Inhibitory Amino ...
... paraventricular thalamic nucleus (PVT), ventral tegmental area (VTA), nucleus of the solitary tract (NTS), perifornical lateral hypothalamus (LH), and the closely aligned arcuate (Arc) and paraventricular (PVN) hypothalamic nuclei ...
... nuclei, including the paratenial, mediodorsal, and paraventricular thalamic nuclei, of which the latter sends a dense projection to the AcbSh (Brog et al., 1993). The infralimbic cortex projects strongly to the LH and VTA, although ...
... Paraventricular Thalamic Nucleus One of the largest projections to the AcbSh arises in the paraventricular thalamic (PVT) nucleus, a member of the midline and intralaminar thalamic complex (Zaborszky et al., 1985; Carlsen and Heimer ...
Contents
1 | |
5 | |
27 | |
67 | |
BrainstemHypothalamic Neuropeptides and the Regulation of Feeding | 99 |
The GutBrain Axis in the Control of Eating | 143 |
Integration of Peripheral Adiposity Signals and Psychological Controls of Appetite | 167 |
Brain Reward Systems for Food Incentives and Hedonics in Normal Appetite and Eating Disorders | 191 |
The Role of Palatability in Control of Human Appetite Implications for Understanding and Treating Obesity | 247 |
Learned Influences on Appetite Food Choice and Intake Evidence in Human Beings | 271 |
Gene Environment Interactions and the Origin of the Modern Obesity Epidemic A Novel Nonadaptive Drift Scenario | 301 |
Preclinical Developments in Antiobesity Drugs | 323 |
Clinical Investigations of Antiobesity Drugs | 337 |
Index | 357 |
Color Plates | 373 |
Pharmacology of Food Taste and Learned Flavor Preferences | 217 |
Other editions - View all
Appetite and Body Weight: Integrative Systems and the Development of Anti ... Tim C. Kirkham,S. J. Cooper No preview available - 2007 |