Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity DrugsTim Kirkham, Steven J Cooper There is now enough basic work to sketch out the principal systems at all levels of the brain, from prefrontal cortex to lower brainstem, which are orchestrated to provide control of food selection, preference and consumption. At the same time, the complex interplay between central systems and signals generated from peripheral systems include the gut, liver and fat stores, as well as the interactions with the neuroendocrine system can be described in some detail. A continuing theme throughout the book is that the functional analysis of appetite and food intake cannot be limited to a single focus, e.g. hypothalamic neuropeptides and their interactions, but must be based on a fully integrated view of the several contributing systems. Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs provides an expert guide to the neural, neurochemical, autonomic and endocrine interrelations which underpin appetite and the controls of food intake and body weight. The book covers many of the neurochemical entities that are currently under investigation, including: neuropeptides, leptin, insulin, monoamines and endogenous cannabinoids in relation to appetite and body-weight control. In addition to the neuroscience analysis, there are also chapters that provide an expert guide to some of the key psychological concepts that the researchers believe are essential in trying to understand the phenomena under investigation. The volume will also serve as an authoritative guide to the current emphasis on the development of novel, efficacious anti-obesity medication.
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From inside the book
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... protein. The argument for including umami as a basic taste has received support from the recent discovery of specific receptors for glutamate in lingual tissue with taste buds (Chaudhari et al., 2000). 1. Central Taste Pathways The ...
... proteins, including odorant binding proteins, enzymes, and antibodies (which help protect the brain from odorant-borne illnesses). The specific olfactory receptor proteins are genetically specified by about 1000 different genes (Buck ...
... protein (AGRP) and a separate population synthesizing the anorexic peptides proopiomelanocortin (POMC) and CART protein (Elias et al., 1998; Hahn et al., 1998). Activity in these neurons is regulated in part by levels of circulating ...
... protein (AgRP) neurons coexpress the NOP1 receptor and nociceptin alters CART and AgRP release. Endocrinology 146, 3526–3534. Bhatnagar, S., and Dallman, M. F. (1999). The paraventricular nucleus of the thalamus alters rhythms in core ...
... Protein distribution of the orexin-2 receptor in the rat central nervous system. Regul. Pept. 104, 131–144. Compan, V., Daszuta, A., Salin, P., Sebben, M., Bockaert, J., and Dumuis, A. (1996). Lesion study of the distribution of ...
Contents
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BrainstemHypothalamic Neuropeptides and the Regulation of Feeding | 99 |
The GutBrain Axis in the Control of Eating | 143 |
Integration of Peripheral Adiposity Signals and Psychological Controls of Appetite | 167 |
Brain Reward Systems for Food Incentives and Hedonics in Normal Appetite and Eating Disorders | 191 |
The Role of Palatability in Control of Human Appetite Implications for Understanding and Treating Obesity | 247 |
Learned Influences on Appetite Food Choice and Intake Evidence in Human Beings | 271 |
Gene Environment Interactions and the Origin of the Modern Obesity Epidemic A Novel Nonadaptive Drift Scenario | 301 |
Preclinical Developments in Antiobesity Drugs | 323 |
Clinical Investigations of Antiobesity Drugs | 337 |
Index | 357 |
Color Plates | 373 |
Pharmacology of Food Taste and Learned Flavor Preferences | 217 |
Other editions - View all
Appetite and Body Weight: Integrative Systems and the Development of Anti ... Tim C. Kirkham,S. J. Cooper No preview available - 2007 |