Neural Transplantation Methods

Front Cover
Stephen B. Dunnett, Alan A. Boulton, Glen B. Baker
Springer Science & Business Media, Oct 20, 1999 - Medical - 556 pages
we might seek alternative sources of donor tissues. Genetic en- neering, expansion of precursor cells, generation of immortalized cell lines, and transplantation between species are all under active investigation. Although significant difficulties remain for each of these alternatives, the problems appear soluble and relevant knowledge is expanding rapidly. As we enter the twenty-first century, the place of neural tra- plantation in experimental neuroscience is continuing to evolve. Rather than being a topic in its own right, neural transplantation increasingly serves as just another technique in the researcher's armory--alongside lesions, pharmaceuticals, gene transfer, and a variety of other techniques--for the experimental manipulation of brain structure and function. This is particularly true for studies of degeneration, plasticity, regeneration, and recovery of function in the nervous system, topics of increasing importance as experimental neurobiology is required to serve the higher needs of neurological and mental health in aging societies. Within this evolving context, Neural Transplantation Methods seeks to serve a particular need: to provide experimental neu- scientists with a source book of information to enable them to select and adapt transplantation techniques to their own expe- mental programs. All authors have been asked to address prac- cal issues, to enable the reader to assess what is available, what are the alternatives, what are the practical issues to be resolved in applying a particular protocol and getting it to work reliably in their unique experimental context.
 

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Contents

Pregraft Tissue Storage Methods for Intracerebral Transplantation
27
Neural Stem Cells for Transplantation
41
Immortalized Cells
55
Cells from Testis for Transplantation in the CNS
73
Engineered Cells and Ex Vivo Gene Transfer
89
Intracerebral Gene Transfer Using Viral Vectors
103
Basic Transplantation Methods in Rodent Brain
133
Neural Transplantation in the Developing CNS
169
Transplanting Myelinogenic Cells into the CNS
305
Labeling and Identifying Grafted Cells
318
Neovascularization and the BloodBrain Barrier
365
Neuroprotective Strategies in Neural Grafting
411
Death and Survival in CNS Grafting
441
Mechanisms of Rejection
461
Immunoprotection of Cell and Tissue Implants in the CNS
477
Immunobiology of Neural Xenotransplantation
503

Preparation of Cell Suspensions for Transplantation
195
Application of PolymerEncapsulated Cell Therapy
233
Neural Transplantation in Parkinsonian Primates
279

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