Cutaneous Melanoma and Precursor LesionsDirk J. Ruiter, Kees Welvaart, Soldano Ferrone In recent years much progress has been made in knowledge and understanding of the biology of cutaneous melanoma. In this respect etiological factors, prognostic factors, antigen expression of melanoma cells, immune response and mechanisms of metastasis formation have to be mentioned. It is the purpose of this book to give a review on fundamental aspects, diagnosis and prognosis, and treatment of cutaneous melanoma and precursor lesions. Moreover, previously unpublished new data are presented. A post-graduate Boerhaave course "Cutaneous Melanoma and Precursor Lesions" was held at Leiden University on 12 and 13 April,. 1984. The proceedings are contained in this volume. The editors would like to thank all speakers and chairpersons on the course, the Boerhaave Committee for its contribution to the organisation of the course, Upjohn Nederland for its financial support and Mrs. I.A. Kruyff for her secretarial assistance. Dirk Ruiter, Kees Welvaart and Soldano Ferrone, Leiden and Valhalla (NY), June, 1984. VII CONTENTS Preface v Contents VII List of First Authors with Co-Authors XI PART I: FUNDAMENTAL ASPECTS. The epidemiology of melanoma R.M. MACKIE The molecular biology of carcinogenesis 9 A.W.M. VAN DER KAMP AND N.G.J. JASPERS 19 Human melanoma associated antigens identified with monoclonal antibodies: characterization and potential clinical application P.G. NATALI, R. CAVLIERE, M. MATSUI, G. BURAGGI, L. CALLEGARO, and S. FERRONE Cellular and molecular parameters of tumor progression in 38 human malignant melanoma J. BRUEGGEN, E.B. BROECKER, L. SUTER, K. REDMANN, and C. |
Contents
THE EPIDEMIOLOGY OF MELANOMA | 1 |
THE MOLECULAR BIOLOGY OF CARCINOGENESIS | 9 |
CHARACTERIZATION AND POTENTIAL CLINICAL APPLICATION | 19 |
CELLULAR AND MOLECULAR PARAMETERS OF TUMOR PROGRESSION IN HUMAN MALIGNANT MELANOMA | 38 |
IMMUNE RESPONSES TO HUMAN MALIGNANT MELANOMA | 57 |
CLINICAL DIAGNOSIS OF CUTANEOUS MELANOMAS VJA van Vloten | 72 |
PATIENTS AND DOCTORS DELAY IN DIAGNOSING AND TREATING MALIGNANT MELANOMA OF THE SKIN | 81 |
HISTOPATHOLOGY OF CUTANEOUS MALIGNANT MELANOMA | 97 |
LONG TERM RESULTS OF RANDOMIZED TRIAL COMPARING IMMEDIATE VERSUS DELAYED NODE DISSECTION IN STAGE I MELAN... | 165 |
LOCAL EXCISION AND REGIONAL PERFUSION IN HIGHRISK STAGEI MALIGNANT MELANOMA OF THE EXTREMITIES | 181 |
THE USE OF CHEMOTHERAPY IN THE MANAGEMENT OF PATIENTS WITH MALIGNANT MELANOMA | 190 |
RADIOTHERAPY OF MALIGNANT MELANOMA | 213 |
CONGENITAL NEVOCELLULAR NEVI | 219 |
CLINICAL ASPECTS OF DYSPLASTIC NEVUS SYNDROME | 227 |
HISTOPATHOLOGICAL ASPECTS OF DYSPLASTIC NEVI | 239 |
CRITICAL REMARKS ON THE DYSPLASTIC NAEVUS SYNDROME | 249 |
IMMUNOHISTOPATHOLOGICAL ASPECTS OF CUTANEOUS MELANOMA AND PRECURSOR LESIONS | 112 |
PROGNOSTIC FACTORS FOR CUTANEOUS MELANOMA | 126 |
INCIDENCE OF RECURRENCE AND SURVIVAL IN CLINICAL STAGE I PATIENTS WITH MELANOMA AFTER LOCAL EXCISION | 143 |
Other editions - View all
Cutaneous Melanoma and Precursor Lesions Dirk J. Ruiter,Kees Welvaart,Soldano Ferrone Limited preview - 2012 |
Cutaneous Melanoma and Precursor Lesions Dirk J Ruiter,Kees Welvaart,Soldano Ferrone No preview available - 1984 |
Cutaneous Melanoma and Precursor Lesions Dirk J. Ruiter,Kees Welvaart,Soldano Ferrone No preview available - 2011 |
Common terms and phrases
Ann Surg antigen expression associated antigens atypia autologous benign biopsies Breslow thickness Cancer Cancer Res Cancer Treat Rep carcinoma cellular chemotherapy Clark level Clark WH clinical Stage cutaneous melanoma cytotoxic Dermatol detected diagnosis differentiation disease free survival dose DTIC Dysplastic Nevus Syndrome familial Ferrone gene growth heterogeneity histological HLA-DR antigens HMW-MAA human malignant melanoma human melanoma cells Immunol incidence lentigo maligna melanoma lesions level of invasion lymph node malignant melanoma melanocytes melanoma cell lines melanoma lines melanoma patients melanoma-associated antigens melphalan metastases metastatic melanoma MeWo MHC antigens Mihm MC MoAb mole monoclonal antibodies naevi naevus Natali PG Natl nevi nevocellular nevi nevomelanocytic node dissection nude mouse oncogene patients with melanoma phenotype pigmented present primary melanomas primary tumor prognostic factors proliferation recurrence regional perfusion regression risk Ruiter satellites skin Stage I melanoma Table therapy transformation treatment tumor cells tumor thickness virus wide excision