New Therapeutic Strategies in Low-Grade GliomasLow-grade glioma (LGG) is a brain infiltrative neoplasia, often invading cortical and subcortical functional structures. It affects young active patients, who usually present with seizures. This work gives insights into different therapeutic strategies that need to be considered for each patient, and the parameters that can help decision making. |
Contents
| 1 | |
| 2 | |
| 4 | |
| 6 | |
| 17 | |
F METABOLIC NEUROIMAGING | 23 |
G CONCLUSIONS | 25 |
ADVANCES IN THE STUDY OF THE INDIVIDUAL DYNAMIC ORGANIZATION OF THE BRAIN | 27 |
B LINKAGE BETWEEN LGG PROGRESSION AND FUNCTIONAL BRAIN RESHAPING | 28 |
ADVANCES IN THERAPEUTIC MANAGEMENT | 31 |
B NEW THERAPEUTIC STRATEGIES | 35 |
REFERENCES | 45 |
ABOUT THE AUTHORS | 87 |
INDEX | 89 |
Common terms and phrases
Acta Neurochir Wien adult analysis anaplasia anaplastic anaplastic transformation and/or angiogenesis anticancer apoptosis astrocytic biological biopsy brain tumors Cancer Res cell lines cellular chemotherapy chromosome Clin Oncol clinical cognitive Correlation cortical deficit diagnosis differentiation Duffau dynamic eloquent areas endothelial epilepsy evaluation eventhough functional glial glioblastoma glioblastoma multiforme glioma cells grade 2 gliomas growth factor growth rate high-grade gliomas histological histological grade human gliomas imaging Int J Radiat intracranial intraoperative lesions low grade low-grade astrocytomas low-grade gliomas malignant gliomas mapping metabolic mixed gliomas molecular motor mutation neoplastic Neurol Neurosurg Psychiatry neurological Neurooncol Neuropathol Exp Neurol Neurosurg Neurosurgery oligoastrocytomas oligodendroglial tumors oligodendrogliomas Oncol Biol Phys oncotypes outcome Pathol pathways patients pediatric phenotype plasticity positron emission tomography prognostic factors proliferation protein Radiat Oncol Biol radiation therapy radiological radiotherapy recurrence risk role stereotactic supratentorial supratentorial low-grade surgery survival temozolomide therapeutic strategy treatment trial tumor cell tumoral growth tumoral volume vascular
Popular passages
Page 59 - Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas.
Page 58 - Rev Neurosci, 1999. 22: p. 511-39. [255] Heesters, MA, et al., Proliferation and apoptosis in long-term surviving low grade gliomas in relation to radiotherapy. J Neurooncol. 2002. 58(2): p. 157-65. [256] Hegi, ME, et al., MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med, 2005. 352(10): p. 997-1003. [257] Heimans, JJ and MJ Taphoorn, Impact of brain tumour treatment on quality of life. J Neural, 2002.
Page 58 - J. Folkman, Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell, 1996. 86(3): p.
Page 58 - CK. et al.. Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol Biol Cell, 1993.
Page 46 - SW, et al., Functional magnetic resonance imaging of regional brain activity in patients with intracerebral gliomas: findings and implications for clinical management. Neurosurgery, 1996.
Page 57 - Glantz, MJ, et al., Identification of early recurrence of primary central nervous system tumors by [18F]fluorodeoxyglucose positron emission tomography. Ann Neurol, 1991.
Page 76 - Prospective randomized trial of low- versus high-dose radiation therapy in adults with supratentorial low-grade glioma: initial report of a North Central Cancer Treatment Group/Radiation Therapy Oncology Group/Eastern Cooperative Oncology Group study. J Clin Oncol 20:2267-2276 4.
Page 49 - Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas.
Page 79 - TS, et al., Descriptive epidemiology of primary brain and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990-1994. Neurooncol, 1999.