Molecular Biology of the Male Reproductive SystemDavid de Kretser Written by experts in their respective fields, this book reviews the expanding knowledge concerning the mechanisms regulating male reproduction at the molecular and cellular levels. It covers the development of the testes and regulatory controls for spermatogenesis and steroidogenesis, and it considers aspects of Sertoli cell function. Areas of emphasis include communication between the various cell types involved in reproduction by hormone and growth factors and the mechanisms by which these factors regulate gene expression. A number of mammalian systems, including humans, are covered. The carefully selected authors provide a clear synopsis of the concepts in each area as well as the latest references, enabling the reader to investigate the topic further. This book is of interest to those seeking an understanding of the regulatory mechanisms in male reproduction and is written for the graduate and postgraduate levels. Key Features * Provides up-to-date reviews of the molecular and cellular biology of male reproduction * Includes chapters on the developmental biology of the testes * Links conventional hormonal control of testicular function with the evolving role of growth factors and proto-oncogenes |
Contents
| 1 | |
| 21 | |
Chapter 3 Nuclear Morphogenesis during Spermiogenesis | 67 |
Chapter 4 Hormonal Control of Spermatogenesis | 99 |
Chapter 5 Patterns of Expression and Potential Functions of Protooncogenes during Mammalian Spermatogenesis | 143 |
Chapter 6 Gene Expression during Spermatogenesis | 181 |
Chapter 7 Molecular Basis of Signaling in Spermatozoa | 233 |
Chapter 8 Paracrine Mechanisms in Testicular Control | 271 |
Chapter 9 Molecular Biology of Iron Transport in the Testis | 311 |
Chapter 10 Molecular Biology of Testicular Steroid Secretion | 327 |
Chapter 11 Hormonal Control Mechanisms of Leydig Cells | 383 |
Chapter 12 Growth Factors in the Control of Testicular Function | 411 |
Chapter 13 Vascular Controls in Testicular Physiology | 439 |
| 469 | |
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Common terms and phrases
Acad acrosome reaction action activity adrenal androgen Androl binding Biochem Biol blood flow bovine c-kit cAMP cDNA cellular Chem cholesterol chromosome culture cyclase cytochrome cytoplasmic differentiation effects encoding Endocrinol Endocrinology enzyme extracellular Fertil fetal Garbers gene expression germ cells GnRH gonadal gonadotropin Griswold growth factor hormone Huhtaniemi human increase induced inhibin inhibition interactions interstitial Jégou Leydig cells LH receptor male mammalian manchette meiosis membrane mitochondria molecular motility mouse mRNA mutations Natl Nature London Nieschlag normal nuclear nucleus pachytene spermatocytes Paranko Parvinen Pelliniemi peptide peritubular cells phosphorylation Proc production protein kinase proto-oncogene rat Sertoli cells rat testis region regulation regulatory Reprod response role secretion seminiferous epithelium seminiferous tubules sequence Sertoli cells side-chain cleavage somatic specific speract sperm spermatids spermatocytes spermatogenesis spermatogenic spermatogenic cells spermatogonia spermatozoa steroid steroidogenesis steroidogenic stimulation structure studies suggesting synthesis testis-specific testosterone tion tissue transcription factors transferrin transgenic vitro