Structure and Function of ApolipoproteinsStructure and Function of Apolipoproteins presents a comprehensive review of the primary and secondary structure of apolipoproteins. The book discusses the structure of the apolipoprotein gene family and genetic variation occurring at the protein level. Functional properties of apolipoproteins, including lipid binding, enzyme co-factor activity, antigenic properties, and receptor-ligand interactions are extensively described and analyzed in relation to their structural features. Physiological properties of apolipoproteins and their role in biology and medicine are also examined. Anyone who is interested in apolipoproteins or is conducting research on atherosclerosis should consider this volume an essential reference. |
Contents
Chapter | 2 |
Apolipoproteins as Lipoprotein Receptor Ligands | 3 |
Apolipoprotein Genes | 13 |
Perspectives | 22 |
Apolipoprotein Gene Expression Structure and Evolution | 33 |
Chapter 3 | 63 |
Chapter 4 | 85 |
Detection and Physiological Relevance of Mutations in | 123 |
Chapter 10 | 175 |
Chapter 7 | 176 |
Chapter 8 | 217 |
Structural | 251 |
Apolipoproteins as Ligands for Lipoprotein Receptors | 269 |
Chapter 11 | 295 |
Chapter 12 | 363 |
Chapter 13 | 401 |
Common terms and phrases
a-helical a-helices A-II A-IV Acad Acta acyl affinity air-water interface allele amino acid amino acid sequence amphipathic amphipathic helices apo A-I apo C-II apolipo apolipoprotein B-100 associated atherosclerosis binding domain Biochemistry Biochim Biol Biophys C-III catalytic cDNA cells CETP characterization Chem cholesterol cholesteryl esters Clin codon colipase complexes concentration containing deficiency discoidal discs DMPC domain of apo effect enzyme epitopes exon Figure function gene genetic Gotto helix high density lipoprotein human apo human apolipoprotein A-I human plasma hydrophobic interaction LCAT LDL receptor lecithin-cholesterol acyltransferase lecithin:cholesterol acyltransferase ligand lipid lipid binding lipid monolayer Lipid Res lipoprotein lipase low density lipoprotein mAbs Mahley metabolism molecular molecules monoclonal antibodies monolayer mRNA mutation N-terminal Natl particles phosphatidylcholine phospholipid plasma plasma lipoproteins polymorphism Pownall Proc protein receptor-binding region rHDL Rosseneu secondary structure Segrest soluble apolipoproteins specific studies substrate synthetic peptides triacylglycerol triglyceride variants vesicles vitro VLDL Weisgraber