Acute Phase Proteins Molecular Biology, Biochemistry, and Clinical ApplicationsAcute Phase Proteins covers all major aspects of acute phase proteins (APP) starting with molecular mechanisms regulating their synthesis and ending with their functional significance. The book features 36 chapters addressing such topics as acute phase response and the APP; major APP and their structure and functions; regulation of APP synthesis, the cytokines and hormones implicated in these processes, and molecular mechanisms involved; signal transduction of cytokines in hepatocytes and posttranscriptional processes; and quantitative and qualitative evaluation of APP in clinical practice. The book will be an important reference for immunologists, molecular biologists, cellular biologists, biochemists, and clinical chemists. |
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Contents
Acute Phase Response | 4 |
Role of Cytokines in Other Acute Phase Phenomena | 13 |
The Negative Acute Phase Proteins | 21 |
Chapter 3 | 28 |
39 | |
I | 40 |
C | 52 |
42 | 73 |
Chapter 17 | 309 |
Chapter 18 | 321 |
Chapter 19 | 329 |
Chapter 20 | 343 |
Regulation of CReactive Protein Haptoglobin and Hemopexin Gene | 365 |
Chapter 22 | 397 |
Chapter 24 | 412 |
Transcriptional Regulation of the Human C3 Gene | 425 |
Chapter 4 | 79 |
3 | 83 |
Chapter 5 | 93 |
Chapter 6 | 107 |
Chapter 7 | 117 |
Chapter 8 | 149 |
Chapter 9 | 169 |
Chapter 10 | 185 |
Chapter 11 | 207 |
Chapter 12 | 223 |
Chapter 13 | 239 |
Chapter 14 | 255 |
Chapter 15 | 275 |
Chapter 16 | 289 |
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Common terms and phrases
a-macroglobulin a₂-M activity acute phase plasma acute phase proteins acute phase response AGP gene al-acid glycoprotein albumin amino acid antibodies assay Baumann binding Biochem Biol biological Biophys C-reactive protein C/EBP cDNA cell lines Chem choroid plexus Clin cloning complement complex concentration culture cystatin cytokines dexamethasone disulfide domain effect elastase fibrinogen fibroblasts Figure function Gauldie gene expression glucocorticoids glycoprotein growth factor haptoglobin Hep G2 cells hepatic hepatocytes hepatoma hepatoma cells hormone human hepatoma IL-6DBP Immunol increase induced inflammation inhibition injection interaction interleukin-6 macrophages mediated mice molecular molecule monocytes mouse mRNA mRNA levels murine Natl neutrophil nuclear pathway peptide phase plasma proteins Proc promoter protein genes protein synthesis proteinase inhibitors rat liver recombinant region regulation residues role Schreiber serpins serum amyloid specific stimulation structure studies subunit thiostatin tissue transcription transfected transferrin transthyretin tumor necrosis factor vitro vivo