Inflammatory Bowel Disease: Translation from Basic Research to Clinical Practice

Front Cover
B. Vucelic, J.F. Colombel, C. Gasche, J. Schölmerich
Springer Science & Business Media, Dec 9, 2004 - Medical - 290 pages

The amount of information on the pathogenesis of inflammatory bowel disease is growing rapidly. This is reflected by a continuous increase in the number of papers presented at international GI meetings. To make things more difficult for practicing physicians, there is also a large number of new clinical trials being published which require periodical critical reviews and recommendations. Faced with these issues, the scientific commitee of the Falk Symposium No. 140 decided to take a different approach and to apply a novel format that is reflected in the title of the Symposium: "Translation from basic research to clinical practice".

This book contains the proceedings of that Symposium, held in Dubrovnik, Croatia, on May 7–8, 2004. The sections are designed so that they start with the information from basic sciences on different aspects of these complex diseases and further lead to their clinical implications. Special attention is paid to the mechanisms of actions of established drugs. The last two sections are clinically oriented and focus on the most difficult aspects of both Crohn's disease and ulcerative colitis. This format provides state-of-the-art chapters by leading experts in the field and at the same time up-to-date information on the clinical application of the new knowledge.

From inside the book

Selected pages

Contents

Molecular classification of inflammatory bowel disease
3
NOD proteins and defence against microbial infection
17
Pharmacogenetics of inflammatory bowel disease therapy
24
Genotypes and phenotypes in clinical practice
34
MICROBIOLOGY
41
Chronic inflammatory disorders the gut and the Old Friends hypothesis
43
Innate immune receptors and inflammatory bowel disease
59
Manipulation of enteric flora in clinical practice
66
Crosssectional imaging in inflammatory bowel disease
154
State of the art the transparent abdomen
158
MECHANISM OF ACTION OF ESTABLISHED DRUGS
165
Apoptosis as a target
167
Mechanisms of action of conventional drugs in inflammatory bowel disease
173
Optimizing the use of current drugs for inflammatory bowel disease
180
THE DIFFICULT CASES OF CROHNS DISEASE
187
Diffuse jejunoileitis in an adolescent
189

IMMUNOREGULATION NOVEL THERAPEUTIC AGENTS
73
Lymphocyte integrins and the pathogenesis of experimental colitis
75
Role of cytokines and their receptors in inflammatory bowel diseases
83
Stateoftheart targeting immunoregulation biologicals
90
MANIPULATION OF THE ENVIRONMENT
99
Environmental epidemiology
101
Understanding the opposite effects of smoking in inflammatory bowel disease
112
Microparticles a link between modern life and inflammatory bowel disease?
123
Are we able to treat inflammatory bowel disease with diet?
138
NEW DIAGNOSTIC TOOLS
147
Novel endoscopic diagnostic developments bioendoscopy
149
Diffuse jejunoileitis in the adolescent patient
196
Current methods of bowelsparing surgery in Crohns disease
202
Mechanisms of steroidrefractory disease
220
Management of perianal Crohns disease
234
THE DIFFICULT CASES OF ULCERATIVE COLITIS
241
A case of refractory proctitis
243
Inflammatory bowel diseases and innate immunity
249
Biology of cancer in ulcerative colitis and consequences for chemoprevention
259
Therapeutic strategy in ulcerative colitis 2004
270
Index
275
Copyright

Common terms and phrases

Bibliographic information