Methods for NEURAL ENSEMBLE RECORDINGSMiguel A. L. Nicolelis Neuroscientists have long recognized the importance of understanding the underlying principles of information processing by large populations of neurons. Methods for Neural Ensemble Recordings explores methods for using electrophysiological techniques for monitoring the concurrent activity of ensembles of single neurons. Since current methods allow one to simultaneously record the extracellular activity of up to 100-150 neurons for days or even weeks, neural ensemble recordings have been used to address long-standing issues in development, learning, memory, sensorimotor integration, sensory information processing, and neuronal plasticity. EXAMINES THE MANY POSSIBLE APPLICATIONS FOR THIS REVOLUTIONARY METHOD Each chapter offers a step-by-step description for the implementation of a particular technique or experimental paradigm employing simultaneous multiple electrode recordings. The techniques described can be used in applications that impact a large group of life scientists, including: |
Contents
| 1 | |
| 25 | |
Trends in Multichannel Neural Ensemble Recording Instrumentation | 47 |
Automatic Discrimination of Single Units | 61 |
Multielectrode Recording from the Cerebellum | 79 |
Methods for Chronic Neuronal Ensemble Recordings in Singing Birds | 101 |
Methods for Simultaneous Multisite Neural Ensemble Recordings in Behaving Primates | 121 |
CorrelationBased Analysis Methods for Neural Ensemble Data | 157 |
Directed Coherence A Tool for Exploring Functional Interactions Among Brain Structures | 179 |
PopulationLevel Analysis of MultiSingle Neuron Recording Data Multivariate Statistical Methods | 193 |
Pitfalls and Problems in the Analysis of Neuronal Ensemble Recordings During Behavioral Tasks | 229 |
Index | 249 |
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action potentials acute recording algorithm amplitude analysis behavioral bins Biomed bird brain calculated cerebellar cortex chronic recording classification climbing fiber clusters coactivity coefficients complex spike connector correlation cortical cross-correlation data set defined dendritic detection directed coherence discrimination distribution encoding ensemble activity ensemble recordings experimental extracellular fiber firing rate function Gerstein hippocampal histograms IEEE Trans implant input insertion insulated interaction JPSTH large numbers latency layer linear matrix measure method microdrive microelectrodes microwire multichannel multielectrode multineuron multiple multivariate neural ensemble neural networks neuron recordings neuronal population neurons Neurophysiol Neurosci Nicolelis output particle patterns population coding population vectors prediction primates principal component procedure Purkinje cell recording sites samples screw signal significant silicon single neurons single unit single unit recording somatosensory spike sorting spike trains statistical stimulus substrate surface techniques temporal bias tissue variables variance waveform whisker wires zebra finch
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