Topical Antimicrobial Testing and Evaluation

Front Cover
CRC Press, Apr 27, 1999 - Science - 224 pages
Providing industry and academia with the ways of getting products approved by the FDA and the means of servicing expanding markets, this work presents and reviews techniques for testing antibacterial compounds. It discusses and illustrates the most effective methods for testing efficacy and safety of preinjection and preoperative washes, healthcare and food service workers' handwashes, and surgical scrubs.
 

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Contents

General Approach to Developing Topical Antimicrobials
1
REDUCTIONISM
4
III CONCLUSION
15
Skin Properties
17
II THE EPIDERMIS
18
III THE DERMIS
21
IV DERMAL VASCULARIZATION
22
V THE TISSUE FLUIDS
24
III STATISTICAL METHODS
78
IV STATISTICAL MODELBUILDING AND ANALYSIS
80
V PARAMETRIC STATISTICS
83
VI NONPARAMETRIC STATISTICS
84
VII QUALITATIVE RESEARCH DESIGNS
85
VIII PHENOMENOLOGICAL DESIGNS
86
IX HEURISTIC DESIGNS
87
X HISTORICAL RESEARCH DESIGN
88

Skin Microbiology
25
II THE BACTERIAL CELL
29
III MYCOLOGY FUNGI
46
IV VIRUSES
50
Current Topical Antimicrobials
53
II CHLORHEXIDINE GLUCONATE
56
III PARACHLOROMETAXYLENOL PCMX
58
IV ALCOHOLS
59
Measurement of Antimicrobial Action of Topical Antimicrobials
61
II THE RESEARCH SITUATION
66
III MICROBIOLOGICAL METHODOLOGY
69
IV STATISTICAL METHODS USED TO EVALUATE THE STUDY
70
V NEW PRODUCT DEVELOPMENT APPLICATIONS
71
VI CONCLUSION
76
Epistemological Requirements in Evaluating the Effects of Specific Treatments
77
XII CONCLUSION
89
Evaluation Strategies and Sample Working Protocols
91
II HEALTHCARE PERSONNEL HANDWASH EVALUATIONS
94
III PROPOSED ANTIMICROBIAL HANDSOAP EVALUATION
96
IV SAMPLE PROTOCOLS to be modified as required
102
IVa GENERALUSE HANDWASH EVALUATION see Section VI Foodhandler Antimicrobial Handwash Evaluation
108
VI FOODHANDLER ANTIMICROBIAL HANDWASH EVALUATION
112
VII MEDICALHEALTHCARE INDUSTRY ANTIMICROBIALS
117
Overview of Statistical Methods
141
II INTRODUCTION TO STATISTICAL INFERENCE
147
III ANALYSIS OF VARIANCE ANOVA
168
IV KRUSKALWALLIS STATISTIC
188
References
199
Index
205
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