Cytochrome Oxidase in Neuronal Metabolism and Alzheimer’s DiseaseFrancisco Gonzalez-Lima This book is based on an international symposium titled "Cytochrome oxidase in energy metabolism and Alzheimer's disease," held as a satellite to the 27th meeting of the Society for Neuroscience, New Orleans, 1997. The symposium was dedicated in honor of Dr. Margaret T. T. Wong-Riley because, in our opinion, the cytochrome oxidase histo chemical method introduced by Dr. Wong-Riley in 1979 was the most significant break through to map energy metabolism in the entire brain since the 2-deoxyglucose method introduced by Dr. Louis Sokoloff and colleagues in 1977. Both of these metabolic map ping techniques have made monumental contributions to brain research by allowing an integral view of brain activity. They have also developed into various specialized tech niques, including applications to the human brain. One of these new applications, which is described in detail in this book, is the quantitative cytochrome oxidase cytochemical method used to study Alzheimer's disease. The objective of this book is to describe the role of cytochrome oxidase in neuronal metabolism and Alzheimer's disease. Whether genetic or environmental, the pathogenesis of Alzheimer's disease involves a cascade of multiple intracellular events, eventually re sulting in failure of oxidative energy metabolism. Could impairment of cytochrome oxi dase in energy metabolism initiate the degenerative process? Cytochrome oxidase function and dysfunction are discussed in relationship to neuronal energy metabolism, neurodegen eration, and Alzheimer's disease. The book is made up of 10 chapters, divided into three major parts. |
From inside the book
Results 1-5 of 84
Page
Sorry, this page's content is restricted.
Sorry, this page's content is restricted.
Page
... Cytochrome Oxidase and Neuroanatomical Patterns : What Is the Connection ? .. Robert F. Hevner 91 4. Functional Mapping of Learning - Related Metabolic Activity with Quantitative Cytochrome Oxidase Histochemistry 109 Amy Poremba , Dirk ...
... Cytochrome Oxidase and Neuroanatomical Patterns : What Is the Connection ? .. Robert F. Hevner 91 4. Functional Mapping of Learning - Related Metabolic Activity with Quantitative Cytochrome Oxidase Histochemistry 109 Amy Poremba , Dirk ...
Page 1
Sorry, this page's content is restricted.
Sorry, this page's content is restricted.
Page 2
Sorry, this page's content is restricted.
Sorry, this page's content is restricted.
Page 3
Sorry, this page's content is restricted.
Sorry, this page's content is restricted.
Contents
Functional Significance and Bigenomic Regulation | 1 |
Theory Methods | 55 |
What Is the Connection? | 91 |
Functional Mapping of LearningRelated Metabolic Activity with Quantitative | 109 |
Functional Imaging Probes to Study the Neural Bases of Behavior in Genetic | 145 |
Alzheimers Disease and Cytochrome Oxidase Dysfunction | 171 |
Molecular Mechanisms of Impaired Mitochondrial Gene Expression | 203 |
Behavioral Electrophysiological and Biochemical Consequences of Chronic | 217 |
Cytochrome Oxidase Atlas of Rat Brain | 263 |
Contributors | 281 |
Other editions - View all
Cytochrome Oxidase in Neuronal Metabolism and Alzheimer’s Disease Francisco Gonzalez-Lima Limited preview - 2013 |
Cytochrome Oxidase in Neuronal Metabolism and Alzheimer’s Disease Francisco Gonzalez-Lima No preview available - 2013 |
Cytochrome Oxidase in Neuronal Metabolism and Alzheimer's Disease Francisco Gonzalez-Lima No preview available - 2014 |
Common terms and phrases
A.D. brain activity units Alzheimer's disease analysis animals auditory cortex auditory system azide treatment behavioral Biochem Blocking brain regions Brain Res Bregma C.O. activity C.O. histochemistry C.O. inhibition C.O. staining C.O. subunit cell bodies cellular cerebral changes Conditioned Excitor correlation cortical cyto cytochrome oxidase cytochrome oxidase activity decreased deficits dendrites dorsal dysfunction effect electron energy metabolism enzyme Figure footshock free radical functional activity gene expression geniculate glia glucose Gonzalez-Lima hippocampus histochemical histochemistry imaging impairment increased incubation inferior colliculus ischemia layer levels marker measured medial membrane memory metabolic capacity molecular mRNA mtDNA neurodegenerative neuronal activity neuronal functional neurons neuropil Neurosci nuclear nuclear-encoded nucleus optical density oxidative metabolism oxygen patterns phosphorylation processing produce Pseudorandom Pseudorandom group quantitative C.O. rat brain reaction reactive receptor regulation sections sodium azide standards structures studies synaptic synthesis techniques tion tissue tone Torre transcription ventral visual cortex