Liver Growth and RepairA. Strain, Anna Mae Diehl Nelson Fausto The Greek myth of Prometheus with its picture of a vulture feasting on its chained victimhas traditionallyprovided a visualimageofliverregeneration. Itis apowerful and frightening representationbut ifone were to substitute the vulture by a surgeon and Prometheus by a patient laying on a properly prepared operating table, the outcomeoftheprocedurewould not differ significantlyfrom that describedbyGreek poets. Yet few of us who work in the field have stopped long enough to ask where this myth originated. Did the poet observe a case of liver regeneration in a human being? Was it brilliant intuition or perhaps, literally, just a 'gut feeling' of a poet looking for good rhymes that led to the prediction that livers grow when part of the tissueisremoved? Thisbookdoesnotattemptto solve these historical issues. Itdoes, instead, cover in detail some of the major modem themes of research on liver regen eration, injury and repair. As indicated in Dr. N. Bucher's chapter, the modem phase ofexperimental studies on liver regeneration started in 1931 with the publication by Higgins and Anderson of a method to perform a two-thirds resection of the liver of a rat. The technique described has 3 remarkable features: 1) it is highly reproducible, resulting in the removal of 68% of the liver, 2) it has minimal if any mortality, and 3) it consists only of blood vessel ligation and does not involve cutting through or wounding hepatic tissue. |
Contents
1 | 4 |
1 | 12 |
1 | 19 |
1 | 28 |
Alterations in membranemediated events during | 34 |
7 | 40 |
Epithelial stemlike cells of the rodent liver | 50 |
3 | 55 |
Intracellular signal transduction in liver regeneration | 366 |
Part Four Biology of the Extracellular Matrix | 403 |
Regulation of collagen gene expression | 430 |
The extracellular matrix in liver regeneration | 451 |
Hepatocyte coculture threedimensional culture models | 465 |
Kupffer cells and endothelial cells | 482 |
Hepatic stellate cells | 512 |
185 | 536 |
4 | 63 |
6 | 80 |
97 | |
Transgenic animals as models for hepatocarcinogenesis | 100 |
3 | 108 |
Gene knockout animal models | 143 |
Biological activity of growth factors in vivo | 163 |
6 | 175 |
The EGFTGF a family of growth factors and their receptors | 185 |
550 | 208 |
The fibroblast growth factor family | 240 |
Cytokines | 283 |
Protooncogenestranscription factors | 297 |
Cyclins and gap junctions in liver growth and repair | 311 |
Other editions - View all
Common terms and phrases
Academy of Sciences activated activation activity albumin animals antigen apoptosis biliary binding Biochemical Journal Biological Chemistry Biology c-myc cell cycle cell proliferation cellular Clinical collagen collagenase connexin cultured cyclin development differentiation DNA synthesis early effects EGFR EMBO Journal epidermal growth factor ethanol evidence expressed extracellular matrix family fibroblast following function gap junctions gene expression gene therapy genes glucagon growth factor HBsAg hepatic hepatitis B virus hepatocarcinogenesis hepatocellular hepatocyte hepatocyte growth factor hepatocytes Hepatology human including increase increased induced induction insulin interaction isolated Journal of Biological kinase Kupffer cells laminin levels liver cells liver growth liver injury liver regeneration matrix model Molecular mouse mRNA National Academy neoplastic Oncogene oval cells partial hepatectomy Pathology patients phosphorylation primary Proceedings protein putrescine rat hepatocytes rats receptor regulation results role Sciences USA shown signaling studies TGFß tissue transcription transforming growth factor transgenic mice transplantation transplanted tumor type tyrosine vitro
References to this book
Hepatocyte Transplantation, Part 3 S. Gupta,Peter L.M. Jansen,J. Klempnauer,M.P. Manns No preview available - 2002 |