The Antidepressant EraThe Antidepressant Era chronicles the history of psychopharmacology from its inception with the discovery of chlorpromazine in 1951 to current battles over whether these powerful chemical compounds should replace psychotherapy. An expert in both the history and the science of neurochemistry and psychopharmacology, David Healy offers a close-up perspective on early research and clinical trials, the stumbling and successes that have made Prozac and Zoloft household names. Most arresting is Healy's insight into the marketing of antidepressants and the medicalization of the neuroses. Demonstrating that pharmaceutical companies are as much in the business of selling psychiatric diagnoses as of selling psychotropic drugs, he raises disturbing questions about how much of medical science is governed by financial interest. |
Contents
Of Illness Disease and Remedies | 7 |
The Discovery of Antidepressants | 43 |
Other Things Being Equal | 78 |
Copyright | |
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5HT reuptake alprazolam American amine amitriptyline antidepressant antipsychotics anxiety appeared argued behavior biological brain British Brodie catecholamine Chapter chlorpromazine Ciba clear clinical trial clinicians clomipramine clozapine cognitive therapy compounds concept depression diagnosis discovery disease dose drug development drug treatments DSM-III efficacy emerged evaluation Geigy Healy hospital idea imipramine insanity interest interpersonal involved iproniazid isoniazid issue Journal of Psychiatry Klerman Kline Kraepelin Kuhn Kuhn's lithium mania MAOIs maprotiline medicine ment mental health mental illness monoamine oxidase Monoamine Oxidase Inhibitors nervous neuroleptics neurotic neurotransmitter norepinephrine Osheroff outcomes panic disorder patients pharmaceutical industry phenelzine physicians placebo possible prescribing problem produced Prozac Psychopharmacology psychotherapy psychotropic drugs randomized RCTs receptor reports reserpine response reuptake inhibitors role schizophrenia Schou scientific seemed Shepherd side effects social phobia specific SSRIs stemmed story studies subsequently suggested therapeutic therapists tion treat tricyclic