Glioblastoma MultiformeTreatment of malignant glioma remains a major challenge for neurosurgeons, neurologists, medical oncologists, and radiation oncologists caring for patients with these tumors. Glioblastoma multiforme, the most common type of brain tumor, is also the most deadly -- only five percent of patients or fewer will be alive at five years after diagnosis. This comprehensive new reference is edited by a renowned team consisting of a neurosurgeon, medical oncologist, oncologic surgeon, and radiation oncologist. The book provides basic researchers and clinicians with a contemporary review of the epidemiology, diagnosis, and treatment of glioblastoma multiforme, and also imparts to experienced investigators outside of the field sufficient background to apply their skills to the treatment of this deadly disease. Expert malignant glioma researchers and clinicians provide state-of-the-art chapters on important topics such as molecular genetic classification of glioblastoma, surgical management, stem cell therapy, chemotherapy, angiogenesis, and more. |
Contents
Chapter 2 | 34 |
Chapter 3 | 40 |
Chapter 4 | 57 |
Chapter 5 | 75 |
Clinical Aspects of Glioblastoma Multiforme | 90 |
Chapter 7 | 108 |
Chapter 8 | 131 |
Chapter 9 | 146 |
Current Chemotherapy for Glioblastoma | 161 |
Common terms and phrases
activation adenovirus agents amplification anaplastic astrocytoma angiogenesis antigens astrocytic BCNU biopsy brain tumors Cancer Res cell cycle cellular chemotherapy Clin clinical trials cytotoxic deletion diagnosis differentiation disease dose efficacy EGFR endothelial enhancing epidermal growth factor expression focal adhesion kinase Gene Ther gene therapy genetic glial glioblastoma cells glioblastoma multiforme glioma cells growth factor receptor herpes simplex virus high-grade gliomas histologic human gliomas immunotherapy increased infiltrative injection Int J Radiat intracranial intraoperative intratumoral lesion LTGBMS lymphocytes magnetic resonance malignant astrocytoma malignant glioma mice migration molecular mutations Natl Acad Sci necrosis Neurooncol Neurosurg Neurosurgery normal brain NSCs oncogenic Oncol Biol Phys oncolytic overexpression pathways patients with GBM phase potential progenitor proliferation protein PTEN Radiat Oncol Biol radiation therapy radiotherapy region replication Reson Imaging signaling stereotactic surgery surgical resection survival T-cell target temozolomide therapeutic tion tissue toxicity transgene tumor cells tyrosine vectors viral viruses vitro vivo