Molecular Genetics, Gene Transfer, and TherapyAnimal science is being transformed by advances in molecular genetics. This book covers this exciting transformation. Both the diagnosis and treatment of disease are discussed in seven chapters by a team of leading international authorities. From oncogenesis and hemophilia to retroviral virulence and genome mapping, this volume yields an understanding of fundamental mechanisms of action and insightful means of diagnosis and treatment. Practicing veterinarians and researchers in animal science will find this book useful. |
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Contents
1 | |
Chapter II Genes Involved in Oncogenesis | 51 |
Chapter III Diagnostic Molecular Genetics | 103 |
Chapter IV Gene Therapy for the Hemophilias | 119 |
Chapter V Genes Controlling Retroviral Virulence | 135 |
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Common terms and phrases
Acad adenovirus alleles amino acid amplification animals bovine chromosome bovine syntenic group breeds cancer candidate gene canine genome carcinoma cattle cDNA cell lines cellular comparative mapping cystic fibrosis deficiency defined deletion detected DNA sequences dogs efficient expression F.IX F.VIII factor IX first function gene product gene therapy gene transfer genetic map haplotypes hemophilia homologous human chromosome human genome hybridization identified immunodeficiency virus inactivation infection insertion kinase large number linkage analysis linkage map loci locus mammalian markers microsatellite molecular molecules mouse mRNA murine Natl normal nucleotide oncogenes oncogenesis phenotype plasmid point mutations polymerase polymorphic positional cloning primers probe Proc protein proto-oncogene proviral receptor recombinant DNA region replication restriction enzyme result retinoblastoma retroviruses RFLP sarcoma signal somatic cell species specific studies syndrome syntenic target techniques tion tissue traits transcription factors transduction transforming transgenic transgenic mice tumor cells tumor-suppressor genes Vande Woude viral viruses Womack