Molecular Genetics, Gene Transfer, and Therapy
Elsevier, Oct 1, 1997 - Technology & Engineering - 227 pages
Animal science is being transformed by advances in molecular genetics. This book covers this exciting transformation. Both the diagnosis and treatment of disease are discussed in seven chapters by a team of leading international authorities. From oncogenesis and hemophilia to retroviral virulence and genome mapping, this volume yields an understanding of fundamental mechanisms of action and insightful means of diagnosis and treatment. Practicing veterinarians and researchers in animal science will find this book useful.
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Chapter II Genes Involved in Oncogenesis
Chapter III Diagnostic Molecular Genetics
Chapter IV Gene Therapy for the Hemophilias
Chapter V Genes Controlling Retroviral Virulence
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Acad adenovirus alleles amino acid ampliﬁcation animals bovine chromosome bovine syntenic group breeds cancer candidate gene canine genome carcinoma cattle cDNA cell lines cellular comparative mapping cystic ﬁbrosis deﬁciency deﬁned deletion detected DNA sequences dogs efﬁcient expression F.IX F.VIII factor IX ﬁrst function gene product gene therapy gene transfer genetic map haplotypes hemophilia homologous human chromosome human genome hybridization identiﬁed immunodeﬁciency virus inactivation infection insertion kinase large number linkage analysis linkage map loci locus mammalian markers microsatellite molecular molecules mouse mRNA murine Natl normal nucleotide oncogenes oncogenesis phenotype plasmid point mutations polymerase polymorphic positional cloning primers probe Proc protein proto-oncogene proviral receptor recombinant DNA region replication restriction enzyme result retinoblastoma retroviruses RFLP sarcoma signal somatic cell species speciﬁc studies syndrome syntenic target techniques tion tissue traits transcription factors transduction transforming transgenic transgenic mice tumor cells tumor-suppressor genes Vande Woude viral viruses Womack