Drug DiscoveryHany El-Shemy Natural products are a constant source of potentially active compounds for the treatment of various disorders. The Middle East and tropical regions are believed to have the richest supplies of natural products in the world. Plant derived secondary metabolites have been used by humans to treat acute infections, health disorders and chronic illness for tens of thousands of years. Only during the last 100 years have natural products been largely replaced by synthetic drugs. Estimates of 200 000 natural products in plant species have been revised upward as mass spectrometry techniques have developed. For developing countries the identification and use of endogenous medicinal plants as cures against cancers has become attractive. Books on drug discovery will play vital role in the new era of disease treatment using natural products. |
Contents
Anticancer Drug Discovery From Serendipity | 35 |
Drug Interactions Pharmacogenomics and Cardiovascular | 75 |
Interactions with Drugs and Dietary Supplements Used | 107 |
Small Molecule Screens to Identify Inhibitors | 157 |
Practical Considerations of Liquid Handling Devices in Drug | 177 |
Data Analysis Approaches in High Throughput Screening | 201 |
Oxidative Stress in Human Infectious Diseases Present | 227 |
Discovery of Selective and Potent Inhibitors | 251 |
Resources for Drug Discovery | 309 |
Transition State Analogues of Enzymatic Reaction | 325 |
Suppression of ProInflammatory Cytokines via Targeting | 373 |
Coupled Enzyme Activity and Thermal Shift Screening of | 413 |
Current Treatments and Preclinical Models | 433 |
Applications of Snake Venom ProlineRich Oligopeptides Bj | 459 |
Introduction to Biochemical Pharmacology and Drug | 475 |
The Antibacterial Drug Discovery | 289 |
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Common terms and phrases
acid activity agents analysis antibacterial antibiotics anticancer antioxidant apoptosis arthritis assay associated bacteria binding bioactive Biochem Biol biological cancer cell carcinogens cardiovascular cell lines Chem chemical clinical trials compounds concentration cysteines cytochrome cytokine decrease diethylpropion disease dose drug discovery effects enzymes ephedra factor flavonoids function gene genetic genome high-throughput high-throughput screening human hypertension identified increase induced infection inhibition inhibitors ISSN John's wort Journal juice kinase leukaemia levels liver mechanism medicine membrane metabolism metabolites methods molecular mutations novel obesity orlistat oxide palmitate palmitoyl palmitoylation parasite pathogens pathway patients peptides pharmacokinetics pharmacological Plasmodium falciparum plate polymorphism potential protein reactions receptor redox regulation resistance response rimonabant risk role screening sibutramine signaling small molecule specific St John's wort STAT proteins structure studies substrate synthesis target TbCK Ther therapeutic therapy tion tissue topiramate toxicity treatment tumor vitro vivo warfarin weight loss Zhang zonisamide