Inflammatory Bowel DiseaseJoseph B. Kirsner World-renowned experts present state-of-the-art information in the clinical understanding of inflammatory bowel disease in the 5th Edition of this best-selling text. Scholarly and pragmatic, this text features authoritative information on the medical and surgical management of IBD with the support of over 390 illustrations. Features many new chapters, including those covering intestinal permeability in health and disease, the intestinal response to acute inflammation and injuries, and current concepts of IBD etiology and pathogenesis. |
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Page 263
... gene Ability to identify gene along a chromosome Advantages Linkage Sibpairs Relative pairs Pedigrees Qualitative : e.g. , presence of disease Quantitative Major genes : easily identified Genes of modest effect : difficult Association ...
... gene Ability to identify gene along a chromosome Advantages Linkage Sibpairs Relative pairs Pedigrees Qualitative : e.g. , presence of disease Quantitative Major genes : easily identified Genes of modest effect : difficult Association ...
Page 264
... gene locus ( the address of the gene ) , this suggests that the association has identified a major gene for the disease . Linkage studies , at the sample sizes currently being conducted , usually can identify only major gene effects ...
... gene locus ( the address of the gene ) , this suggests that the association has identified a major gene for the disease . Linkage studies , at the sample sizes currently being conducted , usually can identify only major gene effects ...
Page 387
... gene expression by the beta - catenin - Tcf - Lef complex has been demonstrated , but the specific genes regulated by these complexes are not yet known . Thus , the normal APC protein appears to be a negative regulator of beta - catenin ...
... gene expression by the beta - catenin - Tcf - Lef complex has been demonstrated , but the specific genes regulated by these complexes are not yet known . Thus , the normal APC protein appears to be a negative regulator of beta - catenin ...
Common terms and phrases
acid activity acute addition adhesion agents altered animals antibodies antigen appears associated bacterial barrier cause changes chronic Clin clinical colonic common complex Crohn's disease cytokines defect demonstrated develop effect enhanced enteric epithelial cells epithelium et al evidence experimental expression factor function Gastroenterol Gastroenterology gene genetic growth factor human immune Immunol important incidence increased induced infection inflammation inflammatory bowel disease inhibition initial injury interactions intestinal epithelial cells involved lamina propria levels lymphocytes lymphoid macrophages major mechanisms mediators mice molecules mucosal muscle neutrophils normal observed occurs oral patients permeability Peyer's patches population present produced protective protein rates rats recent receptor region regulation relatives reported response risk role secretion severe showed shown similar small intestine smoking specific stimulation studies suggest surface T-cell Table tion tissue tolerance treatment ulcerative colitis