Inflammatory Bowel DiseaseJoseph B. Kirsner World-renowned experts present state-of-the-art information in the clinical understanding of inflammatory bowel disease in the 5th Edition of this best-selling text. Scholarly and pragmatic, this text features authoritative information on the medical and surgical management of IBD with the support of over 390 illustrations. Features many new chapters, including those covering intestinal permeability in health and disease, the intestinal response to acute inflammation and injuries, and current concepts of IBD etiology and pathogenesis. |
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Page 119
... rats and for more than 11 weeks in Lewis rats.69-73 The lowest effective dose is approxi- mately 3 mg / kg ; 10 mg / kg very often is lethal . Small intestine enteritis is highly reproducible ( 95 % ) in all strains of rats if the ...
... rats and for more than 11 weeks in Lewis rats.69-73 The lowest effective dose is approxi- mately 3 mg / kg ; 10 mg / kg very often is lethal . Small intestine enteritis is highly reproducible ( 95 % ) in all strains of rats if the ...
Page 129
... rats that possess the human gene for HLA - B27 and ẞ2 - microglobulin . Of the original B27 transgenic lines , only 21-4H , 33-3 , and 21-3 develop spontaneous , multiorgan systemic disease . 179 , 180 The 33-3 line has been maintained ...
... rats that possess the human gene for HLA - B27 and ẞ2 - microglobulin . Of the original B27 transgenic lines , only 21-4H , 33-3 , and 21-3 develop spontaneous , multiorgan systemic disease . 179 , 180 The 33-3 line has been maintained ...
Page 140
... rats given indomethacin . Am J Pathol 1969 ; 54 ( 2 ) : 237 . 68. Davis SW , Holt LC , Sartor RB : Luminal bacterial and bacterial polymers potentiate indomethacin - induced intestinal injury in the rat . Gastroenterology 1990 ; 98 ...
... rats given indomethacin . Am J Pathol 1969 ; 54 ( 2 ) : 237 . 68. Davis SW , Holt LC , Sartor RB : Luminal bacterial and bacterial polymers potentiate indomethacin - induced intestinal injury in the rat . Gastroenterology 1990 ; 98 ...
Common terms and phrases
acid activity acute addition adhesion agents altered animals antibodies antigen appears associated bacterial barrier cause changes chronic Clin clinical colonic common complex Crohn's disease cytokines defect demonstrated develop effect enhanced enteric epithelial cells epithelium et al evidence experimental expression factor function Gastroenterol Gastroenterology gene genetic growth factor human immune Immunol important incidence increased induced infection inflammation inflammatory bowel disease inhibition initial injury interactions intestinal epithelial cells involved lamina propria levels lymphocytes lymphoid macrophages major mechanisms mediators mice molecules mucosal muscle neutrophils normal observed occurs oral patients permeability Peyer's patches population present produced protective protein rates rats recent receptor region regulation relatives reported response risk role secretion severe showed shown similar small intestine smoking specific stimulation studies suggest surface T-cell Table tion tissue tolerance treatment ulcerative colitis