Sleep-Related Breathing Disorders: Experimental Models and Therapeutic PotentialMiodrag Radulovacki Systematically assessing the relative strengths and weaknesses of various animal model systems, this reference presents an overview of the known pathophysiology of sleep-related breathing disorders. It focuses exclusively on animal-based experimental approaches to improve current diagnostic and therapeutic practices in the management of these disorders. Providing a fundamental understanding of sleep-related breathing disorders, the book introduces sleep disorders and applies modern neuroscience to regulation of breathing during sleep. The authors have collected nearly all known studies, summarized the date, and provided easy to understand diagrams, charts, and figures. |
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airway occlusion animal models apnea expression Appl Physiol arousal arterial Baghdoyan baseline behavior Biol blood pressure Brain Res brainstem c-Fos cardiovascular carotid body cells central apneas changes cholinergic chronic Copyright decrease disease diving edited effects electrodes elephant seals English bulldog episodic hypoxia eye movement factor frequency function gene expression human hypercapnia hypertension hypoglossal motoneurons hypoglossal nucleus hypoxia hypoxia-inducible hypoxic increased induced intermittent hypoxia Lung Lydic Marcel Dekker mechanisms mice motoneurons mPRF mRNA muscle activity neck EMG neonatal nerve neural neurons Neurosci NREM nucleus obstructive sleep apnea OSDB oxygen pattern period phasic physiological pontine protein Pulmonary Radulovacki rapid eye movement rats receptor regions regulation REM sleep Respir Crit respiratory response rights reserved serotonin sleep and breathing sleep deprivation sleep fragmentation sleep-disordered breathing sleep-wake SRBD stimulation studies syndrome transcription trigeminal tyrosine hydroxylase upper airway muscle ventilation ventilatory wakefulness