IBD at the End of Its First Century
G. Rogler, F. Kullman, P. Rutgeerts, R.B. Sartor, J. Schölmerich
Springer, Jul 31, 2000 - Medical - 321 pages
Although the first description of patients with what we now call Crohn's disease or ulcerative colitis was published well before 1900, both disorders seem to be diseases of the twentieth century. At the very start of the twenty-first century, it therefore seems appropriate to look back and at the same time look forward and to assess what knowledge has been gained during the last 100 years and in what direction research and thereby clinical practice will go in the future.
This book, the proceedings of Falk Symposium No. 111 held in Freiburg, Germany, on June 19-20 1999, contains contributions from experienced senior scientists on the state of the art in pathophysiology, diagnosis and treatment, together with unpublished and new findings from young researchers. Basic scientists and clinicians are thereby involved in an exchange of information which will lead to new directions for future research and clinical management of inflammatory bowel diseases.
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Susceptibility genes for inflammatory bowel disease
Interleukin18 gene polymorphisms as genetic markers
A Nemetz Z Tulassay J Fehér and A S Peña
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6-mercaptopurine acid acute allele antibiotics antibody antigens apoptosis associated azathioprine bacteria CD4+ cell lines chromosome Clin Invest clinical colonic controlled trial Crohn's disease crypt cyclosporin cytokines dendritic cells dose drug effects epithelial cells erythrocyte experimental expression Falk Symposium Figure function Gastroenterol Gastroenterology gastrointestinal gene genetic growth factor IFN-y ileal immune system Immunol increased induced inflammation inflammatory bowel disease inhibition interactions interleukin interleukin-10 intestinal epithelial cells intravenous ISBN Lactobacillus lamina propria linkage lymphocytes macrophages mediated mesalazine metabolite mice migration molecules mucosal murine myofibroblasts necrosis factor neutrophils NF-kB normal oral tolerance pathogenesis pathway patients with Crohn's patients with ulcerative peptides phenotype placebo Podolsky DK polymorphisms pouch pouchitis probiotic proinflammatory protein rats receptor refractory remission role small bowel steroids stimulation studies subgroups surgery susceptibility thalidomide therapeutic therapy TNF-a toxicity TPMT treatment trefoil tumor necrosis ulcerative colitis vitro