Beyond the Cognitive Map: From Place Cells to Episodic Memory
MIT Press, 1999 - Medical - 420 pages
There are currently two major theories about the role of the hippocampus, a distinctive structure in the back of the temporal lobe. One says that it stores a cognitive map, the other that it is a key locus for the temporary storage of episodic memories. A. David Redish takes the approach that understanding the role of the hippocampus in space will make it possible to address its role in less easily quantifiable areas such as memory. Basing his investigation on the study of rodent navigation--one of the primary domains for understanding information processing in the brain--he places the hippocampus in its anatomical context as part of a greater functional system.
Redish draws on the extensive experimental and theoretical work of the last 100 years to paint a coherent picture of rodent navigation. His presentation encompasses multiple levels of analysis, from single-unit recording results to behavioral tasks to computational modeling. From this foundation, he proposes a novel understanding of the role of the hippocampus in rodents that can shed light on the role of the hippocampus in primates, explaining data from primate studies and human neurology. The book will be of interest not only to neuroscientists and psychologists, but also to researchers in computer science, robotics, artificial intelligence, and artificial life.
Results 1-5 of 6
Two key experimental effects have driven hippocampal studies: 1. In the rodent.
Although the hippocampus is far removed from sensory stimuli, in the freely
moving rodent, hippocampal pyramidal cells show a remarkable correlation to
While postsubicular head direction cells are best correlated with current head
direction, anterior thalamic head direction cell activity is best correlated with head
direction approximately 20—40 ms in the future (Blair and Sharp, 1995; Taube ...
Cells in other areas also show more complicated correlations than the simple
orientation correlations that the term head direction cell implies. For example,
lateral mammillary cell activity is strongly correlated with angular velocity as well
Recording from NAcb cells in a standard working memory task on the radial-arm
maze, Lavoie and Mizumori (1994) found three major correlations to firing rate:
place, reward, and movement. Some of the reward-correlated cells were actually
In addition to sensitivity to reward availability, Eichenbaum and colleagues (
Eichenbaum et al., 1987; Eichenbaum and Cohen, 1988; Otto and Eichenbaum,
1992a; see also Sakurai, 1990b) found that some cells are correlated with