Origins and Directions of Inflammatory Bowel Disease: Early Studies of the Nonspecific Inflammatory Bowel Diseases

Front Cover
Springer Science & Business Media, Dec 31, 2001 - Medical - 246 pages
Few human illnesses today are so challenging, medically, scientifically, and socio-economically, as the "nonspecific" inflammatory bowel diseases (IBD): ulcerative colitis and Crohn's disease. Originating several centuries ago but essentially diseases of the 20th century, often attacking children and young adults, involving all bodily systems as well as the gastrointestinal tract, ulcerative colitis and Crohn's disease have emerged in recent decades as among the more "glamorous" unsolved diseases, presenting unusual opportunities for insightful clinical and investigative study. Many of the prevailing concepts originated during the early and mid 20th century. The purpose of Origins and Directions of Inflammatory Bowel Disease is to review these earlier studies and their evolution "from the mystical to the molecular," and guide investigators and physicians through the challenging clinical and scientific maze of IBD.
 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

Introduction
1
Ulcerative Colitis
13
BEGINNINGS
14
INCREASING CLINICAL RECOGNITION
24
INITIAL PATHOLOGY OF ULCERATIVE COLITIS AND ITS PATHOGENETIC IMPLICATIONS
30
PATHOLOGY ELECTRON MICROSCOPY ULCERATIVE COLITIS
39
NATURAL AND EXPERIMENTAL ULCERATIVE COLITIS
40
REFERENCES
43
PSYCHOGENIC ASPECTS UC CD
112
MICROBIAL ASPECTS ULCERATIVE COLITIS
121
MICROBIAL ASPECTS CROHNS DISEASE
126
IMMUNE MECHANISMS
133
M CELL
154
EPITHELIAL PERMEABILITY
155
INFLAMMATION CYTOKINES LYMPHOKINES
156
GENETIC ASPECTS OF INFLAMMATORY BOWEL DISEASE EARLY OBSERVATIONS
161

Crohns disease
55
EARLY CLINICAL RECOGNITION
58
ANIMAL AND EXPERIMENTAL CROHNS DISEASE
63
THE EARLY MT SINAI NEW YORK EXPERIENCE
67
MORE EARLY 20TH CENTURY REPORTS CD
71
CROHNS DISEASE OF THE COLON DELAYED RECOGNITION
77
EARLY PATHOLOGY OF CROHNS DISEASE
81
ELECTRON MICROSCOPY CROHNS DISEASE
85
ORIGIN OF EPONYM OF CROHNS DISEASE
87
REFERENCES
90
Etiology and Pathogenesis of IBD Origins and Directions
103
CONCLUDING COMMENTARY
167
REFERENCES
173
Appendix
205
The Early Treatment of Inflammatory Bowel Disease
207
REFERENCES
219
Pharmacological Development of Aminosalicylates for the Treatment of Inflammatory Bowel Disease
227
REFERENCES
232
Additional Early Publications on Inflammatory Bowel Disease
235
Index
237
Copyright

Other editions - View all

Common terms and phrases

Bibliographic information