Origins and Directions of Inflammatory Bowel Disease: Early Studies of the Nonspecific Inflammatory Bowel DiseasesFew human illnesses today are so challenging, medically, scientifically, and socio-economically, as the "nonspecific" inflammatory bowel diseases (IBD): ulcerative colitis and Crohn's disease. Originating several centuries ago but essentially diseases of the 20th century, often attacking children and young adults, involving all bodily systems as well as the gastrointestinal tract, ulcerative colitis and Crohn's disease have emerged in recent decades as among the more "glamorous" unsolved diseases, presenting unusual opportunities for insightful clinical and investigative study. Many of the prevailing concepts originated during the early and mid 20th century. The purpose of Origins and Directions of Inflammatory Bowel Disease is to review these earlier studies and their evolution "from the mystical to the molecular," and guide investigators and physicians through the challenging clinical and scientific maze of IBD. |
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Contents
Introduction | 1 |
Ulcerative Colitis | 13 |
BEGINNINGS | 14 |
INCREASING CLINICAL RECOGNITION | 24 |
INITIAL PATHOLOGY OF ULCERATIVE COLITIS AND ITS PATHOGENETIC IMPLICATIONS | 30 |
PATHOLOGY ELECTRON MICROSCOPY ULCERATIVE COLITIS | 39 |
NATURAL AND EXPERIMENTAL ULCERATIVE COLITIS | 40 |
REFERENCES | 43 |
PSYCHOGENIC ASPECTS UC CD | 112 |
MICROBIAL ASPECTS ULCERATIVE COLITIS | 121 |
MICROBIAL ASPECTS CROHNS DISEASE | 126 |
IMMUNE MECHANISMS | 133 |
M CELL | 154 |
EPITHELIAL PERMEABILITY | 155 |
INFLAMMATION CYTOKINES LYMPHOKINES | 156 |
GENETIC ASPECTS OF INFLAMMATORY BOWEL DISEASE EARLY OBSERVATIONS | 161 |
Crohns disease | 55 |
EARLY CLINICAL RECOGNITION | 58 |
ANIMAL AND EXPERIMENTAL CROHNS DISEASE | 63 |
THE EARLY MT SINAI NEW YORK EXPERIENCE | 67 |
MORE EARLY 20TH CENTURY REPORTS CD | 71 |
CROHNS DISEASE OF THE COLON DELAYED RECOGNITION | 77 |
EARLY PATHOLOGY OF CROHNS DISEASE | 81 |
ELECTRON MICROSCOPY CROHNS DISEASE | 85 |
ORIGIN OF EPONYM OF CROHNS DISEASE | 87 |
REFERENCES | 90 |
Etiology and Pathogenesis of IBD Origins and Directions | 103 |
CONCLUDING COMMENTARY | 167 |
REFERENCES | 173 |
Appendix | 205 |
The Early Treatment of Inflammatory Bowel Disease | 207 |
REFERENCES | 219 |
Pharmacological Development of Aminosalicylates for the Treatment of Inflammatory Bowel Disease | 227 |
REFERENCES | 232 |
235 | |
237 | |
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Origins and Directions of Inflammatory Bowel Disease: Early Studies of the ... Joseph B. Kirsner No preview available - 2013 |
Common terms and phrases
abdominal acid active agent allergy antibodies antigen Arch associated autoantibodies autoimmune bacterial Bargen biopsies Chir chronic ulcerative colitis colectomy coli colitis and Crohn's colonic mucosa Crohn's disease cytokines demonstrated described diarrhea dysentery early Engl eosinophils epidemiologic epithelial cells epithelium etiology experimental factors fecal Gastroenterology gastrointestinal tract genetic granulomas histologic Hospital ileitis ileostomy immune response Immunol immunologic incidence infection inflammation inflammatory bowel disease involved JAMA Kirsner JB Kruiningen Lancet lesions London lymphocytes lymphoid mast cells Mesalazine microbial microflora Morson mucosa nonspecific ulcerative colitis normal observed Palmer WL pathogenesis pathogenic Pathol pathology patients with Crohn's patients with ulcerative permeability Proc protein psychogenic rabbits rats rectal rectum regional enteritis regional ileitis reported resection role Scand J Gastroenterol serum Shorter RG Sinai small intestine sulfasalazine Surg surgical terminal ileum therapeutic therapy tissue reaction treatment Truelove University of Chicago York