Pharmacological Regulation of Gene Expression in the CNS Towards an Understanding of Basal Ganglial FunctionsThis book focuses on dopamine-mediated regulation of gene expression within the striatum and associated regions of the central nervous system. It is an excellent review of experimental data on interactions between neuronal systems at systemic, cellular, and molecular levels. Each of the chapters, written by the world's leading scientists, provides an understanding of anatomy, neurochemistry, and cellular and molecular effects. Such an understanding sheds light on the pathophysiology of central disorders involving the basal ganglia and leads to new approaches for the treatment of diseases such as Parkinson's disease and schizophrenia, and also addictions to psychostimulants such as cocaine and amphetamines. |
Contents
Introduction | 4 |
DopamineMediated ImmediateEarly Gene Regulation | 11 |
Conclusions | 20 |
Chapter 2 | 25 |
Chapter 3 | 51 |
NEUROTRANSMITTER INTERACTIONS | 79 |
A Critical Role | 115 |
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Pharmacological Regulation of Gene Expression in the CNS Towards an ... Kalpana Merchant Limited preview - 2017 |
Pharmacological Regulation of Gene Expression in the CNS Towards an ... Kalpana Merchant No preview available - 2017 |
Common terms and phrases
Acad acetylcholine acetylcholine release acute administration AFOSB alterations amphetamine antipsychotic antisense knockout antisense oligodeoxynucleotides APDs apomorphine atypical basal ganglia behavioral binding blockade Brain Res c-fos c-fos expression c-fos mRNA cells cholinergic chronic clozapine cocaine D₁ D1 agonist D1 and D2 D₂ antisense D2 dopamine receptor D2 receptors D2-like decrease DLSt dopamine receptor dopaminergic dose drugs dynorphin EAA receptor effects enkephalin excitatory functional gene expression Gerfen globus pallidus glutamate receptor glutamatergic haloperidol immunoreactivity increase induction of c-fos infusion inhibition injection input interactions intrastriatal lesions levodopa mediated mg/kg Molecular mRNA mRNA expression mRNA levels muscarinic Natl Neurochem neuroleptic neuropeptide Neurosci neurotensin nigrostriatal NT/N mRNA nucleus accumbens oligo opioid pathway peptide Pharmacol pharmacological postsynaptic Proc proenkephalin projection neurons protein psychostimulant quinpirole rat striatum receptor agonist receptor antagonists receptor mRNA receptor stimulation receptor subtypes regulation response scopolamine striatal neurons striatonigral neurons striatopallidal neurons studies substantia nigra target transcription zif268 mRNA