Advances in Research on Neurodegeneration, Volume 6Werner Poewe, Gerhard Ransmayr The book contains original articles and reviews presented at the 6th International Winter Conference on Neurodegeneration, held from November 20a "23, 1997 in KitzbA1/4hel/Austria. The aim of this conference was to present and discuss recent data on the interface between neuroimmunology and neurodegeneration, in particular susceptibility to autoimmune and neurodegenerative processes, neuroprotection and restorative treatment strategies. These issues were discussed in the light of recent developments in multiple sclerosis, Parkinsona (TM)s disease, amyotrophic lateral sclerosis, Huntingtona (TM)s disease and multisystem atrophy. The articles highlight topics, which are particularly interesting for the clinician and the neuroscientist. Some of the neuroprotective strategies have already been developed or are at present clinically investigated. The neuroprotective role of deep brain stimulation, antiglutamatergic therapy and apomorphine will be verified in clinical studies in the near future. This is also the case for future therapeutic approaches to restoration of the damaged nervous system, such as somatic gene therapy, implantation of genetically modified cell-lines and medically controlled and directed development of embryonic cells. The conference highlighted the role of the glia, which seems to play a key role, both in traditionally as neuroimmunological and neurodegenerative disorders classified diseases, as indicated above. The topics discussed in the book are significant for recent developments in clinical neurology and neuroscience, as shown in the current literature and at international congresses. |
From inside the book
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Contents
Cell differentiation in the embryonic mammalian spinal cord | |
why are myelin sheaths susceptible to damage? | 5 |
Molecular mimicry and multiple sclerosis a possible role for degenerate T cell recognition in the induction of autoimmune responses | 15 |
what is the place of the newer compounds in the treatment of Parkinsons disease? | 29 |
Apomorphine has a potent antiproliferative effect on Chinese hamster ovary cells | 43 |
Potent neuroprotective and antioxidant activity of apomorphine in MPTP and 6hydroxydopamine induced neurotoxicity | 53 |
Neuroprotective effect of chronic inactivation of the subthalamic nucleus in a rat model of Parkinsons disease | 67 |
Antiglutamate therapy of ALS which is the next step? | 76 |
Antiglutamate therapies in Huntingtons disease | 92 |
a review | 98 |
Striatal reconstruction by striatal grafts | 110 |
Somatic gene therapy in animal models of Parkinsons disease | 126 |
Other editions - View all
Advances in Research on Neurodegeneration: Volume 6 Werner Poewe,Gerhard Ransmayr Limited preview - 2012 |
Advances in Research on Neurodegeneration, Volume 6 Werner Poewe,Gerhard Ransmayr No preview available - 1999 |
Common terms and phrases
6-hydroxydopamine activity amino acid amyotrophic lateral sclerosis animal models antigen apomorphine astrocytes autoimmune Björklund Brain Res bromocriptine cabergoline central nervous system CHO-K1 cells clinical degeneration demyelination differentiation dopamine agonists dopamine receptors dopaminergic dopaminergic neurons drug Dunnett SB dyskinesia excitatory excitotoxic Exp Neurol free radical function Gassen gene therapy genetically glial globus pallidus glutamate Huntington's disease induced inhibition injection intrastriatal L-dopa levodopa mechanisms mice mitochondrial molecular motor neuron Mov Disord MPTP multiple sclerosis multiple system atrophy multipotent mutation myelin sheaths neural Neurochem neurodegenerative Neurology neuroprotective effect Neurosci neurotoxicity neurotrophic factor nigrostriatal NMDA oligodendrocytes oxidative Parkinson's disease pathogenesis patients with Parkinson's peptide Pharmacol pramipexole precursor cells radical scavenging rat model riluzole ropinirole spinal cord stem cells striatal striatal grafts striatum substantia nigra substantia nigra pars subthalamic nucleus therapeutic tion tissue toxic transgenic transplantation treatment vector vitro vivo gene therapy Youdim MBH