Systematic Approach to Evaluation of Mouse Mutations

Front Cover
John P. Sundberg
CRC Press, Jul 23, 1999 - Medical - 216 pages
Experts from The Jackson Laboratory and around the world provide practical advice on everything from how to establish a colony to where to go for specific mutations. The book includes information on medical photography, grafting procedures, and how to map the genes and evaluate the special biological characteristics of mice. It also discusses how to maintain a colony of mice that breed with difficulty, how to approach mapping spontaneous mutations, how to set up systems to evaluate a specific antibody, how to perform simple measurements that yield a large amount of information, and how to access mouse informatics on the Web.

From inside the book

Contents

Introduction
Chapter 1 Colony Establishment
Chapter 2 Determining the Genetic Basis of a New Trait
Chapter 3 Computerized Colony Management
Chapter 4 Medical Record Keeping for Project Analysis
viii
Biological Characterization of a New Mutation
xvii
Chapter 6 Photography of Laboratory Mice
i
Chapter 7 Comparative Pathology and Animal Model Development
xi
Chapter 9 Ultrastructural Evaluation of Mouse Mutations
xxix
Chapter 10 Immunohistochemical and Immunofluorescence Methods
xxxviii
Chapter 11 Radiolabeled cRNA and In Situ Hybridization
2
Chapter 12 Use of Nonradiolabeled Probes for In Situ Hybridization
24
Chapter 13 Repositories of Mouse Mutations and Inbred Congenic and Recombinant Inbred Strains
34
Index
191
Back cover
200
Copyright

Chapter 8 Kinetics and Morphometrics
xx

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About the author (1999)

John P. Sundberg, Dawnalyn Boggess

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