Brain Norepinephrine: Neurobiology and TherapeuticsGregory A. Ordway, Michael A. Schwartz, Alan Frazer Norepinephrine is a chemical neurotransmitter. Drugs that directly manipulate central nervous system (CNS) norepinephrine are being developed targeting noradrenergic neurons to deliver therapeutic effects. Noradrenergic drugs have been proven effective for depression and ADHD, and new disease indications are being identified. A team of experts provides the reader with a thorough understanding of the anatomy, physiology, molecular biology, pharmacology and therapeutics of norepinephrine in the brain, including an extensive review of the role of norepinephrine in brain diseases. The book is divided into four sections: the basic biology of norepinephrine; the role that norepinephrine plays in behavior; evidence of norepinephrine's role in CNS diseases, and the pharmacology and therapeutics of noradrenergic drugs in the treatment of psychiatric and neurological disorders. |
From inside the book
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Page 18
... enhanced in the LC during slow-wave and paradoxical sleep.77 Further studies78 have shown that GABAA receptors within the LC are composed of a unique combination of subunits, 331 . More recent evidence, however, has revealed the ...
... enhanced in the LC during slow-wave and paradoxical sleep.77 Further studies78 have shown that GABAA receptors within the LC are composed of a unique combination of subunits, 331 . More recent evidence, however, has revealed the ...
Page 26
... enhanced when applied beyond the proximal segment of the den- drite. Larkhum and Zhu135 further reported that layer 5 pyramidal neurons have a low-threshold zone in the distal apical dendrite that initiates predominantly Ca2+- dependent ...
... enhanced when applied beyond the proximal segment of the den- drite. Larkhum and Zhu135 further reported that layer 5 pyramidal neurons have a low-threshold zone in the distal apical dendrite that initiates predominantly Ca2+- dependent ...
Page 34
... enhance the firing rate of LC neurons in vivo. Interestingly, a number of these findings corre- sponded with the results of Hagan et al.166 Extracellular recordings of the sponta- neous activity of rat LC neurons revealed an increase of ...
... enhance the firing rate of LC neurons in vivo. Interestingly, a number of these findings corre- sponded with the results of Hagan et al.166 Extracellular recordings of the sponta- neous activity of rat LC neurons revealed an increase of ...
Page 52
... Enhanced nor- epinephrine release in prefrontal cortex with burst stimulation of the locus coeruleus . Brain Res . , 742 ( 1996 ) , 89–97 . 189. Foote , S. L. , Freedman , R. and Oliver , A. P. Effects of putative neurotransmitters on ...
... Enhanced nor- epinephrine release in prefrontal cortex with burst stimulation of the locus coeruleus . Brain Res . , 742 ( 1996 ) , 89–97 . 189. Foote , S. L. , Freedman , R. and Oliver , A. P. Effects of putative neurotransmitters on ...
Page 65
... enhanced noradrenaline turnover in rat brain. Life Sci., 24 (1979), 417–420. 57. Fodor, M., Gorc, T. J. and Palkovits, M. Immunohistochemical study on the distribution of neuropeptides within the pontine tegmentum–particularly the ...
... enhanced noradrenaline turnover in rat brain. Life Sci., 24 (1979), 417–420. 57. Fodor, M., Gorc, T. J. and Palkovits, M. Immunohistochemical study on the distribution of neuropeptides within the pontine tegmentum–particularly the ...
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a2-adrenergic a2-adrenoceptor acid ADHD adrenergic receptors adrenoceptor afferent agonist allele alterations amygdala animals antagonist antidepressant antinociceptive anxiety associated Aston-Jones atomoxetine axons behavioral binding Biochem Biol brain regions Brain Res catecholamine cells central chronic Clin clinical clonidine cognitive cortical CREB decreased depletion desipramine disease disorder dopamine dorsal drugs effects enhanced epinephrine evidence function gene genetic hippocampus human imipramine impaired increased induced inhibition injections innervation input interaction involved kinase LC activity LC neurons lesions levels locus coeruleus locus coeruleus neurons major depression mechanisms mediated memory consolidation mice modulation monkeys monoamine Neurochem neurons Neurosci neurotransmitter noradrenaline noradrenergic noradrenergic neurons noradrenergic system norepinephrine transporter nucleus pathways patients peripheral Pharmacol pharmacological phasic placebo plasma polymorphism postmortem prefrontal cortex presynaptic protein Psychiatry PTSD rat brain reboxetine regulation release response role schizophrenia selective serotonin sleep spinal stimulation stress stress-induced studies subtypes suggest symptoms synaptic target tonic treatment tyrosine hydroxylase uptake venlafaxine
Popular passages
Page 139 - J. AND IVERSEN, LL: Regional studies of catecholamines in the rat brain. IV. Effects of drugs on the disposition and metabolism of H3-norepinephrine and H'-dopamine.
Page 47 - Distribution of substance P-like immunoreactivity in the central nervous system of the rat. I. Cell bodies and nerve terminals.
Page 382 - Goodman WK, Price LH, Delgado PL, et al: Specificity of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder: comparison of fluvoxamine and desipramine. Arch Gen Psychiatry...
Page 554 - Paroxetine: a selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study.
Page 52 - Double dissociation between the involvement of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in startle increases produced by conditioned versus unconditioned fear.
Page 139 - Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.
Page 587 - JL (1996). Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder.
Page 191 - PW (2000) Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine and autonomic responses to stress in primates. Proc. Natl. Acad. Sci. USA, 97: 6079-6084.
Page 116 - Nibuya M, Nestler EJ, Duman RS (1996) Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus, J Neurosci 16:2365-72.