Untranslated gene regions and other non-coding elements : regulation of eukaryotic gene expression
"There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as ""junk DNA"", it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5' and 3' untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution"--Ebook's opening screen (EBL platform, viewed October 9, 2013)
Internet Resources
1 online resource (viii, 56 pages) : illustrations (some color)
9783034806794, 9783034806787, 9781299856059, 3034806795, 3034806787, 1299856055
852405689
1. Untranslated gene regions and other non-coding elements. 1. Introduction
2. Promoter. 2.1 Types of promoter; 2.2 Complex factor interactions; 2.3 Alternative promoters; 2.4 Bidirectional promoters
3. 5' untranslated region. 3.1 Structure ; 3.2 Regulatory motifs
4. Intronic regions. 4.1 Organization and length; 4.2 Introns in the UTRs; 4.3 Intron function; 4.4 Regulatory elements: enhancers
5. 3' Untranslated region. 5.1 MicroRNAs and the 3'UTR; 5.2 stabilisation and AU-rich elements; 5.3 Structure
6. Non-coding RNAs. 6.1 Promoter associated RNAs (PROMPTs); 6.2 Short Interfering RNA (siRNA); 6.3 Piwi-interacting RNAs (piRNAs); 6.4 Small nuclear RNA (snRNA); 6.5 Cis-natural antisense transcripts; 6.6 Long non-coding RNAs; 6.7 RNAs as extracellular signalling molecules; 6.8 Pseudogenes and non-coding RNA; 6.9 Non-coding capacity in primates; 6.10 Competing endogenous RNAs; 6.11 Chimeric RNAs. Preface; Contents; 1 Untranslated gene regions and other non-coding elements; Abstract; 1 ... Introduction; 2 ... Promoter; 2.1 Types of promoter; 2.1.1 Focused promoters; 2.1.2 Dispersed promoters; 2.2 Complex factor interactions; 2.3 Alternative promoters; 2.4 Bidirectional promoters; 2.5 Conclusion; 3 ... 5vprime untranslated region; 3.1 Structure; 3.1.1 5vprime cap structure; 3.1.2 Secondary structure; 3.1.3 G-Quadruplexes; 3.1.4 Alternative 5vprimeUTRs; 3.2 Regulatory motifs; 3.2.1 IRES and cap-independent translation initiation; 3.2.2 uORFs; 3.3 Conclusion; 4 ... Intronic regions. 4.1 Organization and length4.2 introns in the UTRs; 4.3 Intron function; 4.4 Regulatory elements: enhancers; 5 ... 3vprime Untranslated region; 5.1 MicroRNAs and the 3vprimeUTR; 5.2 stabilisation and AU-rich elements; 5.3 structure; 5.3.1 Poly(A) Tail; 5.3.2 5vprime
3vprime interactions; 5.3.3 length; 5.3.4 secondary structure; 5.3.5 Alternative 3vprimeUTRs; 5.4 Conclusions; 6 ... Non-coding RNAs; 6.1 Promoter associated RNAs (PROMPTs); 6.2 Short Interfering RNA (siRNA); 6.3 Piwi-interacting RNAs (piRNAs); 6.4 Small nuclear RNA (snRNA); 6.5 Cis-natural antisense transcripts; 6.6 Long non-coding RNAs. 6.7 RNAs as extracellular signalling molecules6.8 Pseudogenes and non-coding RNA; 6.9 Non-coding capacity in primates; 6.10 Competing endogenous RNAs; 6.11 Chimeric RNAs; 7 ... Conclusion; References
English