Microsystem technology : powerful tool for biomolecular studies
The understanding of molecular informa tion handling in nature is essential for the molecular optimization in chem istry, molecular biology, molecular pharmacology and therefore - as an ex ample - for the development of specifically acting drugs.
581 pages : illustrations ; 24 cm
9783764357740, 3764357746
1027905271
1 Molecular building principles in nature.- 2 Robotic equipment and microsystem technology in biological research.- 3 Components and systems for microliquid handling.- 4 Nanotiterplates for screening and synthesis.- 5 Chip technology for micro-separation.- 6 Rapid multisample PCR in miniaturized ultrathin-walled microwell plates.- 7 Generation of large libraries.- 8 Generation and screening of solution-phase synthetic peptide combinatorial libraries.- 9 Using oligonucleotide probe arrays to access genetic diversity.- 10 Generation of libraries by print technologies.- 11 Synthesis and screening of bead-based libraries.- 12 Sensors for biomolecular studies.- 13 Fluorescence detection of single molecules applicable to small volume assays.- 14 Fluorescence correlation spectrometry (FCS): Measuring biological interactions in microstructures.- 15 Scanning force microscopy: A microstructured device for imaging, probing, and manipulation of biomolecules at the nanometer scale.- 16 DNA resequencing, mutation detection and gene expression analysis of oligonucleotide microchips.- 17 Miniaturized arrays for DNA analysis.- 18 Manipulation of particles, cells and liquid droplets by high frequency electric fields.- 19 Optical trapping and manipulation.- 20 Computer modeling of protein, nucleic acid, and drug structures.- 21 Optimizing structure and function relationship of nucleic acid molecules.- 22 Optimisation of molecular function.- 23 Appendix.